1. University Medical Center of the Johannes Gutenberg University Mainz Department of Neurology, Focus Program Translational Neuroscience (FTN) and Immunotherapy (FZI), Rhine Main Neuroscience Network (rmn2), , 55131 Mainz , Germany
2. Institute of Physiology, University Medical Center of the Johannes Gutenberg University Mainz , 55128 Mainz , Germany
3. University Medical Center of the Johannes Gutenberg University Mainz Department of Dermatology, , 55131 Mainz , Germany
4. European Medicines Agency , 1083HS Amsterdam, Th e Netherlands