Alterations in the brain functional network of abstinent male individuals with methamphetamine use disorder

Author:

Luo Dan1,He Wanlin2,Shen Danlin1,Tang Bin3,Tao Hongge3,Tang Qiao1,Lai Mingfeng1,Liu Jun4,Liu Yishan4,Xu Jiajun1,Meng Jinli2,Li Jing1

Affiliation:

1. Mental Health Center, West China Hospital of Sichuan University , No. 28 Dian Xin Nan Jie, Wuhou District, Chengdu , China

2. Radiology Department, Hospital of Chengdu Office of People’s Government of Tibetan Autonomous Region (Hospital. C.T.) , No. 20, Xi Mian Qiao Heng Jie, Wuhou District, Chengdu , China

3. Chengdu Compulsory Detoxification Center , No. 9 Xue Fu Lu, Shuangliu District, Chengdu , China

4. Sichuan Drug Rehabilitation Administration , No. 90 Shu Tong Jie, Jinniu District, Chengdu , China

Abstract

Abstract Methamphetamine is a highly addictive psychostimulant drug that is abused globally and is a serious threat to health worldwide. Unfortunately, the specific mechanism underlying addiction remains unclear. Thus, this study aimed to investigate the characteristics of functional connectivity in the brain network and the factors influencing methamphetamine use disorder in patients using magnetic resonance imaging. We included 96 abstinent male participants with methamphetamine use disorder and 46 age- and sex-matched healthy controls for magnetic resonance imaging. Compared with healthy controls, participants with methamphetamine use disorder had greater impulsivity, fewer small-world attributes of the resting-state network, more nodal topological attributes in the cerebellum, greater functional connectivity strength within the cerebellum and between the cerebellum and brain, and decreased frontoparietal functional connectivity strength. In addition, after controlling for covariates, the partial correlation analysis showed that small-world properties were significantly associated with methamphetamine use frequency, psychological craving, and impulsivity. Furthermore, we revealed that the small-word attribute significantly mediated the effect of methamphetamine use frequency on motor impulsivity in the methamphetamine use disorder group. These findings may further improve our understanding of the neural mechanism of impulse control dysfunction underlying methamphetamine addiction and assist in exploring the neuropathological mechanism underlying methamphetamine use disorder-related dysfunction and rehabilitation.

Funder

STI 2030-Major Projects

Hospital-level Key Project of the Hospital of Chengdu Office of People’s Government of Tibetan Autonomous Region

Publisher

Oxford University Press (OUP)

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