Longitudinal associations between resting-state, interregional theta-beta phase-amplitude coupling, psychological distress, and wellbeing in 12–15-year-old adolescents

Author:

Sacks Dashiell D1,Schwenn Paul E1,Boyes Amanda1,Mills Lia1,Driver Christina1,Gatt Justine M2,Lagopoulos Jim1,Hermens Daniel F1

Affiliation:

1. Thompson Institute, University of the Sunshine Coast , 12 Innovation Parkway, Birtinya, QLD 4575 , Australia

2. Neuroscience Research Australia (NeuRA), University of New South Wales , Margarete Ainsworth Building, Barker Street, Sydney, Randwick, NSW 2031 , Australia

Abstract

Abstract Cross-frequency coupling between the phase of slower oscillatory activity and the amplitude of faster oscillatory activity in the brain (phase-amplitude coupling; PAC), is a promising new biological marker for mental health. Prior research has demonstrated that PAC is associated with mental health. However, most research has focused on within-region theta-gamma PAC in adults. Our recent preliminary study found increased theta-beta PAC was associated with increased psychological distress in 12 year olds. It is important to investigate how PAC biomarkers relate to mental health and wellbeing in youth. Thus, in this study, we investigated longitudinal associations between interregional (posterior–anterior cortex) resting-state theta-beta PAC (Modulation Index [MI]), psychological distress and wellbeing in N = 99 adolescents (aged 12–15 years). In the right hemisphere, there was a significant relationship, whereby increased psychological distress was associated with decreased theta-beta PAC and psychological distress increased with increased age. In the left hemisphere, there was a significant relationship, whereby decreased wellbeing was associated with decreased theta-beta PAC and wellbeing scores decreased with increased age. This study presents novel findings demonstrating longitudinal relationships between interregional, resting-state theta-beta PAC and mental health and wellbeing in early adolescents. This EEG marker may facilitate improved early identification of emerging psychopathology.

Funder

Australian Commonwealth Government’s “Prioritising Mental Health Initiative”

Australian Government Research Training Program (RTP) Scholarship

Publisher

Oxford University Press (OUP)

Subject

Cellular and Molecular Neuroscience,Cognitive Neuroscience

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