Relationship between the interlimb transfer of a visuomotor learning task and interhemispheric inhibition in healthy humans

Author:

Paparella Giulia1ORCID,De Riggi Martina2,Cannavacciuolo Antonio1ORCID,Colella Donato2ORCID,Costa Davide2,Birreci Daniele2,Passaretti Massimiliano2ORCID,Angelini Luca2ORCID,Guerra Andrea12ORCID,Berardelli Alfredo12ORCID,Bologna Matteo12ORCID

Affiliation:

1. IRCCS Neuromed , Via Atinense 18, Pozzilli, (IS) 86077 , Italy

2. Department of Human Neurosciences, Sapienza University of Rome , Viale dell’Università, 30, 00185 Rome , Italy

Abstract

Abstract The “interlimb transfer” phenomenon consists of improved performance of the trained and untrained contralateral limbs after unilateral motor practice. We here assessed whether a visuomotor learning task can be transferred from one hemisphere to the other, whether this occurs symmetrically, and the cortical neurophysiological correlates of this phenomenon, focusing on interhemispheric connectivity measures. We enrolled 33 healthy subjects (age range: 24–73 years). Participants underwent two randomized sessions, which investigated the transfer from the dominant to the nondominant hand and vice versa. Measures of cortical and intracortical excitability and interhemispheric inhibition were assessed through transcranial magnetic stimulation before and after a visuomotor task. The execution of the visuomotor task led to an improvement in motor performance with the dominant and nondominant hands and induced a decrease in intracortical inhibition in the trained hemisphere. Participants were also able to transfer the visuomotor learned skill. The interlimb transfer, however, only occurred from the dominant to the nondominant hand and positively correlated with individual learning-related changes in interhemispheric inhibition. We here demonstrated that the “interlimb transfer” of a visuomotor task occurs asymmetrically and relates to the modulation of specific inhibitory interhemispheric connections. The study results have pathophysiological, clinical, and neuro-rehabilitative implications.

Publisher

Oxford University Press (OUP)

Subject

Cellular and Molecular Neuroscience,Cognitive Neuroscience

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