Poor Self-Reported Sleep is Related to Regional Cortical Thinning in Aging but not Memory Decline—Results From the Lifebrain Consortium

Author:

Fjell Anders M12,Sørensen Øystein1,Amlien Inge K1,Bartrés-Faz David3,Brandmaier Andreas M45,Buchmann Nikolaus6,Demuth Ilja7,Drevon Christian A89,Düzel Sandra4,Ebmeier Klaus P10,Ghisletta Paolo11,Idland Ane-Victoria11213,Kietzmann Tim C1415,Kievit Rogier A14,Kühn Simone416,Lindenberger Ulman45,Magnussen Fredrik1,Macià Didac3,Mowinckel Athanasia M1,Nyberg Lars17,Sexton Claire E101819,Solé-Padullés Cristina3,Pudas Sara17,Roe James M1ORCID,Sederevicius Donatas1,Suri Sana1019,Vidal-Piñeiro Didac1,Wagner Gerd20,Watne Leiv Otto12,Westerhausen René1,Zsoldos Enikő1019,Walhovd Kristine B12

Affiliation:

1. Center for Lifespan Changes in Brain and Cognition, University of Oslo, 0315 Oslo, Norway

2. Department of Radiology and Nuclear Medicine, Oslo University Hospital, 0188 Oslo, Norway

3. Departament de Medicina, Facultat de Medicina i Ciències de la Salut, Institut de Neurociències, Universitat de Barcelona, 08007 Barcelona, Spain

4. Center for Lifespan Psychology, Max Planck Institute for Human Development, 14195 Berlin, Germany

5. Max Planck UCL Centre for Computational Psychiatry and Ageing Research, Berlin, Germany, and London, UK

6. Department of Cardiology, Charité - University Medicine Berlin Campus Benjamin Franklin, 12203 Berlin, Germany

7. Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Lipid Clinic at the Interdisciplinary Metabolism Center, Charité - Universitätsmedizin Berlin, BCRT - Berlin Institute of Health Center for Regenerative Therapies, 10117 Berlin, Germany

8. Vitas AS, Research Park, Gaustadalleen 21, 0349 Oslo, Norway

9. Department of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, 0315 Oslo, Norway

10. Department of Psychiatry, University of Oxford, Oxford OX1 2JD UK

11. Faculty of Psychology and Educational Sciences, Swiss Distance University Institute, Swiss National Centre of Competence in Research LIVES, University of Geneva, 1205 Geneva, Switzerland

12. Oslo Delirium Research Group, Department of Geriatric Medicine, University of Oslo, 0315 Oslo, Norway

13. Institute of Basic Medical Sciences, University of Oslo, 0315 Oslo, Norway

14. MRC Cognition and Brain Sciences Unit, University of Cambridge, Cambridge CB2 1TN, UK

15. Donders Institute for Brain, Cognition and Behaviour, Radboud University, 6525 XZ Nijmegen, The Netherlands

16. Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany

17. Umeå Center for Functional Brain Imaging, Umeå University, 901 87 Umeå, Sweden

18. Global Brain Health Institute, Department of Neurology, University of California, San Francisco, San Francisco, CA 94143, USA

19. Wellcome Centre for Integrative Neuroimaging, University of Oxford, Oxford OX1 2JD, UK

20. Psychiatric Brain and Body Research Group, Department of Psychiatry and Psychotherapy, Jena University Hospital, 07743 Jena, Germany

Abstract

Abstract We examined whether sleep quality and quantity are associated with cortical and memory changes in cognitively healthy participants across the adult lifespan. Associations between self-reported sleep parameters (Pittsburgh Sleep Quality Index, PSQI) and longitudinal cortical change were tested using five samples from the Lifebrain consortium (n = 2205, 4363 MRIs, 18–92 years). In additional analyses, we tested coherence with cell-specific gene expression maps from the Allen Human Brain Atlas, and relations to changes in memory performance. “PSQI # 1 Subjective sleep quality” and “PSQI #5 Sleep disturbances” were related to thinning of the right lateral temporal cortex, with lower quality and more disturbances being associated with faster thinning. The association with “PSQI #5 Sleep disturbances” emerged after 60 years, especially in regions with high expression of genes related to oligodendrocytes and S1 pyramidal neurons. None of the sleep scales were related to a longitudinal change in episodic memory function, suggesting that sleep-related cortical changes were independent of cognitive decline. The relationship to cortical brain change suggests that self-reported sleep parameters are relevant in lifespan studies, but small effect sizes indicate that self-reported sleep is not a good biomarker of general cortical degeneration in healthy older adults.

Funder

EU Horizon 2020

European Research Council

Norwegian Research Council

National Association for Public Health

Medical Student Research Program at the University of Oslo

Spanish Ministry of Economy and Competitiveness

Walnuts and Healthy Aging

German Federal Ministry of Education and Research

Publisher

Oxford University Press (OUP)

Subject

Cellular and Molecular Neuroscience,Cognitive Neuroscience

Cited by 21 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3