Adult alcohol drinking and emotional tone are mediated by neutral sphingomyelinase during development in males-Reference-Cited by-同舟云学术

Adult alcohol drinking and emotional tone are mediated by neutral sphingomyelinase during development in males

Published:2022-03-16 Issue:3 Volume:33 Page:844-864
ISSN:1047-3211
Container-title:Cerebral Cortex
language:en
Short-container-title:

Author:

Kalinichenko Liubov S¹,Mühle Christiane¹,Jia Tianye²³^ORCID,Anderheiden Felix¹,Datz Maria¹,Eberle Anna-Lisa¹,Eulenburg Volker⁴⁵,Granzow Jonas¹,Hofer Martin¹,Hohenschild Julia¹,Huber Sabine E¹,Kämpf Stefanie¹,Kogias Georgios¹,Lacatusu Laura¹,Lugmair Charlotte¹,Taku Stephen Mbu¹,Meixner Doris¹,Sembritzki Nina-Kristin¹,Praetner Marc¹⁶,Rhein Cosima¹⁷,Sauer Christina¹,Scholz Jessica¹,Ulrich Franziska¹,Valenta Florian¹,Weigand Esther¹,Werner Markus¹,Tay Nicole²,Mc Veigh Conor J⁸,Haase Jana⁸,Wang An-Li⁹,Abdel-Hafiz Laila⁹,Huston Joseph P⁹,Smaga Irena¹⁰,Frankowska Malgorzata¹⁰,Filip Malgorzata¹⁰,Lourdusamy Anbarasu¹¹¹²,Kirchner Philipp¹³,Ekici Arif B¹³,Marx Lena M¹,Suresh Neeraja Puliparambil¹,Frischknecht Renato¹⁴¹⁵,Fejtova Anna¹,Saied Essa M¹⁶¹⁷¹⁸,Arenz Christoph¹⁶,Bozec Aline¹⁹²⁰,Wank Isabel²¹,Kreitz Silke²¹,Hess Andreas²¹,Bäuerle Tobias²²,Ledesma Maria Dolores²³,Mitroi Daniel N²³,Miranda André M²⁴²⁵,Oliveira Tiago Gil²⁴²⁵,Lenz Bernd¹²⁶,Schumann Gunter¹²²⁷²⁸,Kornhuber Johannes¹,Müller Christian P¹²⁹^ORCID

Affiliation:

1. Department of Psychiatry and Psychotherapy, University Clinic, Friedrich-Alexander-University of Erlangen-Nürnberg , Schwabachanlage 6, Erlangen 91054, Germany

2. The Centre for Population Neuroscience and Stratified Medicine (PONS), ISTBI, Fudan University , Shanghai 200433, China

3. PONS Centre and SGDP Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London , London SE5 8AB, UK

4. Department for Anesthesiology and Intensive Care , Faculty of Medicine, , Leipzig 04103, Germany

5. University of Leipzig , Faculty of Medicine, , Leipzig 04103, Germany

6. Biomedical Center, Institute of Cardiovascular Physiology and Pathophysiology, Faculty of Medicine, Ludwig-Maximilians-Universität München , Munich 82152, Germany

7. Department of Psychosomatic Medicine and Psychotherapy, Friedrich-Alexander-University of Erlangen-Nürnberg , Erlangen 91054, Germany

8. School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin , Dublin 4, Ireland

9. Center for Behavioral Neuroscience, Institute of Experimental Psychology, University of Düsseldorf , Düsseldorf 40225, Germany

10. Department of Drug Addiction Pharmacology, Maj Institute of Pharmacology, Polish Academy of Sciences , Smetna 12, Kraków 31-343, Poland

11. Division of Child Health , Obstetrics and Gynaecology, , Nottingham NG7 2UH, UK

12. School of Medicine, University of Nottingham , Obstetrics and Gynaecology, , Nottingham NG7 2UH, UK

13. Institute of Human Genetics, Friedrich Alexander University of Erlangen-Nuremberg (FAU) , Erlangen 91054, Germany

14. Department of Biology , Animal Physiology, , Erlangen 91058, Germany

15. Friedrich-Alexander-University of Erlangen-Nürnberg , Animal Physiology, , Erlangen 91058, Germany

16. Institute for Chemistry, Humboldt University , Berlin 12489, Germany

17. Chemistry Department , Faculty of Science, , Ismailia 41522, Egypt

18. Suez Canal University , Faculty of Science, , Ismailia 41522, Egypt

19. Department of Internal Medicine 3—Rheumatology and Immunology, Friedrich-Alexander-University of Erlangen-Nürnberg , Erlangen 91054, Germany

20. Deutsches Zentrum für Immuntherapie (DZI) , Erlangen 91054, Germany

21. Department of Experimental and Clinical Pharmacology and Toxicology, Emil Fischer Center, Friedrich-Alexander-University of Erlangen-Nuremberg (FAU) , Erlangen, Germany

22. Preclinical Imaging Platform Erlangen, Institute of Radiology, University Hospital Erlangen , Erlangen 91054, Germany

23. Centro Biologia Molecular Severo Ochoa (CSIC-UAM) , Madrid 28040, Spain

24. School of Medicine, Life and Health Sciences Research Institute (ICVS), University of Minho , Campus Gualtar, Braga 4710-057, Portugal

25. ICVS/3B's—PT Government Associate Laboratory , Braga/Guimarães 4710-057, Portugal

26. Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health (CIMH), Medical Faculty Mannheim, Heidelberg University , J5, Mannheim 68159, Germany

27. Department of Psychiatry and Psychotherapie , CCM, , Berlin 10117, Germany

28. PONS Centre, Charite Mental Health, Charite Universitaetsmedizin Berlin , CCM, , Berlin 10117, Germany

29. Centre for Drug Research, Universiti Sains Malaysia , 11800 Minden, Penang, Malaysia

Abstract

Abstract Alcohol use, abuse, and addiction, and resulting health hazards are highly sex-dependent with unknown mechanisms. Previously, strong links between the SMPD3 gene and its coded protein neutral sphingomyelinase 2 (NSM) and alcohol abuse, emotional behavior, and bone defects were discovered and multiple mechanisms were identified for females. Here we report strong sex-dimorphisms for central, but not for peripheral mechanisms of NSM action in mouse models. Reduced NSM activity resulted in enhanced alcohol consumption in males, but delayed conditioned rewarding effects. It enhanced the acute dopamine response to alcohol, but decreased monoaminergic systems adaptations to chronic alcohol. Reduced NSM activity increased depression- and anxiety-like behavior, but was not involved in alcohol use for the self-management of the emotional state. Constitutively reduced NSM activity impaired structural development in the brain and enhanced lipidomic sensitivity to chronic alcohol. While the central effects were mostly opposite to NSM function in females, similar roles in bone-mediated osteocalcin release and its effects on alcohol drinking and emotional behavior were observed. These findings support the view that the NSM and multiple downstream mechanism may be a source of the sex-differences in alcohol use and emotional behavior.

Funder

Deutsche Forschungsgemeinschaft

Johannes und Frieda Marohn-Stiftung

Maj Institute of Pharmacology Polish Academy of Sciences

Federal Ministry of Education and Research

Publisher

Oxford University Press (OUP)

Subject

Cellular and Molecular Neuroscience,Cognitive Neuroscience

Link

https://academic.oup.com/cercor/article-pdf/33/3/844/48513181/bhac106.pdf

Reference84 articles.