Sex differences in fetal brain functional network topology

Author:

Liu Jing12,Zhang Yujin12,Jia Fenglin12,Zhang Hongding12,Luo Lekai12,Liao Yi12,Ouyang Minglei12,Yi Xiaoxue12,Zhu Ruixi12,Bai Wanjing12,Ning Gang12,Li Xuesheng12,Qu Haibo12

Affiliation:

1. West China Second University Hospital, Sichuan University Department of Radiology, , Chengdu 610041, Sichuan, P.R. China

2. Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University) Ministry of Education, , Chengdu 610041, Sichuan, P.R. China

Abstract

Abstract The fetal period is a critical stage in brain development, and understanding the characteristics of the fetal brain is crucial. Although some studies have explored aspects of fetal brain functional networks, few have specifically focused on sex differences in brain network characteristics. We adopted the graph theory method to calculate brain network functional connectivity and topology properties (including global and nodal properties), and further compared the differences in these parameters between male and female fetuses. We found that male fetuses showed an increased clustering coefficient and local efficiency than female fetuses, but no significant group differences concerning other graph parameters and the functional connectivity matrix. Our study suggests the existence of sex-related distinctions in the topological properties of the brain network at the fetal stage of development and demonstrates an increase in brain network separation in male fetuses compared with female fetuses.

Funder

National Key Research and Development Program of China

Publisher

Oxford University Press (OUP)

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