Oxytocin Modulates Neural Individuation/Categorization Processing of Faces in Early Face-Selective Areas

Abstract

Abstract Oxytocin (OT) is known as a neuropeptide that promotes social adaptation. Individuating racial in-group members and viewing racial out-groups in categories is an adaptive strategy that evolved to aid effective social interaction. Nevertheless, whether OT modulates the neural individuation/categorization processing of racial in-group and out-group faces remain unknown. After intranasal OT or placebo administration, 46 male participants (OT: 24, placebo: 22) were presented with face pairs with the same or different identities or races in rapid succession. The neural repetition suppression (RS) effects to identity and race were measured using functional magnetic resonance imaging (fMRI) as indices of individuation/categorization face-processing. The results showed that while OT increased the RS effect to race, it decreased the RS effect to identity in the right fusiform face area. As for the left occipital face area, OT enlarged the differential RS effects to identities of in-group and out-group faces. Additionally, OT modulated the association of interdependence self-construal and the RS effects on identity and race. These findings bring to light preliminary evidence that OT can regulate neuronal specificity of identity and race in early face-selective regions and benefit adaptive individuation/categorization face-processing.