Simultaneous PET/fMRI revealed increased motor area input to subthalamic nucleus in Parkinson’s disease

Author:

Zang Zhenxiang123ORCID,Song Tianbin123,Li Jiping42,Nie Binbin56,Mei Shanshan72,Zhang Chun123,Wu Tao89,Zhang Yuqing42,Lu Jie123

Affiliation:

1. Department of Radiology and Nuclear Medicine , Xuanwu Hospital, , Changchun Rd. 45, Xicheng district, Beijing 100053 , China

2. Capital Medical University , Xuanwu Hospital, , Changchun Rd. 45, Xicheng district, Beijing 100053 , China

3. Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics , Changchun Rd. 45, Xicheng district, Beijing 100053 , China

4. Beijing Institute of Functional Neurosurgery , Xuanwu Hospital, , Changchun Rd. 45, Xicheng district, Beijing 100053 , China

5. Beijing Engineering Research Center of Radiographic Techniques and Equipment , Institute of High Energy Physics, , Yuquan Rd. 19, Shijingshan district, Beijing 100049 , China

6. Chinese Academy of Sciences , Institute of High Energy Physics, , Yuquan Rd. 19, Shijingshan district, Beijing 100049 , China

7. Department of Neurology , Xuanwu Hospital, , Changchun Rd. 45, Xicheng district, Beijing 100053 , China

8. Department of Neurobiology , Neurology and Geriatrics, , Changchun Rd. 45, Xicheng district, Beijing 100053 , China

9. Xuanwu Hospital of Capital Medical University, National Clinical Research Center for Geriatric Disorders , Neurology and Geriatrics, , Changchun Rd. 45, Xicheng district, Beijing 100053 , China

Abstract

Abstract Invasive electrophysiological recordings in patients with Parkinson’s disease (PD) are extremely difficult for cross-sectional comparisons with healthy controls. Noninvasive approaches for identifying information flow between the motor area and the subthalamic nucleus (STN) are critical for evaluation of treatment strategy. We aimed to investigate the direction of the cortical-STN hyperdirect pathway using simultaneous 18F-FDG-PET/functional magnetic resonance imaging (fMRI). Data were acquired during resting state on 34 PD patients and 25 controls. The ratio of standard uptake value for PET images and the STN functional connectivity (FC) maps for fMRI data were generated. The metabolic connectivity mapping (MCM) approach that combines PET and fMRI data was used to evaluate the direction of the connectivity. Results showed that PD patients exhibited both increased FDG uptake and STN-FC in the sensorimotor area (PFDR < 0.05). MCM analysis showed higher cortical-STN MCM value in the PD group (F = 6.63, P = 0.013) in the left precentral gyrus. There was a high spatial overlap between the increased glucose metabolism and increased STN-FC in the sensorimotor area in PD. The MCM approach further revealed an exaggerated cortical input to the STN in PD, supporting the precentral gyrus as a target for treatment such as the repetitive transcranial magnetic stimulation.

Funder

Beijing Municipal Administration of Hospitals

Huizhi Ascent Project of Xuanwu Hospital

Publisher

Oxford University Press (OUP)

Subject

Cellular and Molecular Neuroscience,Cognitive Neuroscience

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