Neural attenuation: age-related dedifferentiation in the left occipitotemporal cortex for visual word processing-Reference-Cited by-同舟云学术

Neural attenuation: age-related dedifferentiation in the left occipitotemporal cortex for visual word processing

Published:2023-01-03 Issue:10 Volume:33 Page:6111-6119
ISSN:1047-3211
Container-title:Cerebral Cortex
language:en
Short-container-title:

Author:

Xue Licheng¹²,Lv Yating³⁴⁵,Zhao Jing¹⁵

Affiliation:

1. Jing Hengyi School of Education, Hangzhou Normal University , No. 2318 Yuhangtang Rd, Yuhang District, Hangzhou 311121 , China

2. Institute for Brain Research and Rehabilitation, South China Normal University , No. 55 Zhongshan Avenue West Rd, Tianhe District, Guangzhou 510631 , China

3. Center for Cognition and Brain Disorders, The Affiliated Hospital of Hangzhou Normal University , No. 126 Wenzhou Rd, Gongshu District, Hangzhou 311121 , China

4. Institute of Psychological Sciences, Hangzhou Normal University , No. 2318 Yuhangtang Rd, Yuhang District, Hangzhou 311121 , China

5. Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments , No. 2318 Yuhangtang Rd, Yuhang District, Hangzhou 311121 , China

Abstract

Abstract The present study investigated the age-related neural basis of cognitive decline in the left ventral occipitotemporal cortex (vOT)—a brain area that responds selectively to visual words processing. Functional magnetic resonance imaging was used to estimate neural activity in this area, while young and old adults viewed words and line drawings. Our results demonstrated the existence of neural dedifferentiation of the left vOT in old adults during visual word processing. More specifically, this dedifferentiation was due to neural attenuation that is, decreased response to words rather than increased response to line drawings in old adults compared with young adults. In addition, individuals who showed decreased neural response to words had worse performance in visual word processing. Taken together, our findings support the neural attenuation hypothesis for the cognitive decline in visual word processing in old adults.

Funder

Hangzhou Normal University

National Science Foundation of China

Publisher

Oxford University Press (OUP)

Subject

Cellular and Molecular Neuroscience,Cognitive Neuroscience

Link

https://academic.oup.com/cercor/article-pdf/33/10/6111/50251018/bhac488.pdf

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