Integration of Eye-Centered and Landmark-Centered Codes in Frontal Eye Field Gaze Responses

Author:

Bharmauria Vishal1ORCID,Sajad Amirsaman12,Li Jirui1,Yan Xiaogang1,Wang Hongying1,Crawford John Douglas13

Affiliation:

1. Centre for Vision Research and Vision: Science to Applications (VISTA) Program, York University, Toronto, Ontario, Canada M3J 1P3

2. Vanderbilt Vision Research Center, Vanderbilt University, Nashville, TN 37240, USA

3. Departments of Psychology, Biology and Kinesiology & Health Sciences, York University, Toronto, Ontario, Canada M3J 1P3

Abstract

Abstract The visual system is thought to separate egocentric and allocentric representations, but behavioral experiments show that these codes are optimally integrated to influence goal-directed movements. To test if frontal cortex participates in this integration, we recorded primate frontal eye field activity during a cue-conflict memory delay saccade task. To dissociate egocentric and allocentric coordinates, we surreptitiously shifted a visual landmark during the delay period, causing saccades to deviate by 37% in the same direction. To assess the cellular mechanisms, we fit neural response fields against an egocentric (eye-centered target-to-gaze) continuum, and an allocentric shift (eye-to-landmark-centered) continuum. Initial visual responses best-fit target position. Motor responses (after the landmark shift) predicted future gaze position but embedded within the motor code was a 29% shift toward allocentric coordinates. This shift appeared transiently in memory-related visuomotor activity, and then reappeared in motor activity before saccades. Notably, fits along the egocentric and allocentric shift continua were initially independent, but became correlated across neurons just before the motor burst. Overall, these results implicate frontal cortex in the integration of egocentric and allocentric visual information for goal-directed action, and demonstrate the cell-specific, temporal progression of signal multiplexing for this process in the gaze system.

Funder

Canadian Institutes for Health Research

Science to Applications Program

Ontario Graduate Scholarship

Canada Research Chair Program

Publisher

Oxford University Press (OUP)

Subject

Cellular and Molecular Neuroscience,Cognitive Neuroscience

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