Acquisition of Spatial Search Strategies and Reversal Learning in the Morris Water Maze Depend on Disparate Brain Functional Connectivity in Mice

Author:

Shah Disha123ORCID,Verhoye Marleen1,Van der Linden Annemie1,D’Hooge Rudi2

Affiliation:

1. Bio-Imaging Lab, Department of Biomedical Sciences, University of Antwerp, Universiteitsplein 1, Wilrijk, Belgium

2. Laboratory of Biological Psychology, Department of Psychology, KU Leuven, Tiensestraat 102, Leuven, Belgium

3. Laboratory for the Research of Neurodegenerative Diseases, Department of Neuroscience, VIB center for Brain and Disease Research, KU Leuven, O&N4 Herestraat 49, Leuven, Belgium

Abstract

Abstract Learning has been proposed to coincide with changes in connections between brain regions. In the present study, we used resting-state fMRI (rsfMRI) to map brain-wide functional connectivity (FC) in mice that were trained in the hidden-platform version of the Morris water maze. C57BL6 mice were investigated in a small animal MRI scanner following 2, 10, or 15 days of acquisition learning, or 5 days of reversal learning. Spatial learning coincided with progressive and changing FC between telencephalic regions that have been implemented in spatial learning (such as hippocampus, cingulate, visual, and motor cortex). Search strategy assessment demonstrated that the use of cognitively advanced spatial strategies correlated positively with extensive telencephalic connectivity, whereas non-spatial strategies correlated negatively with connectivity. FC patterns were different and more extensive after reversal learning compared with after extended acquisition learning, which could explain why reversal learning has been shown to be more sensitive to subtle functional defects.

Funder

EU Seventh Framework Programme Imaging of Neuroinflammation in Neurodegenerative Diseases INMiND

Molecular Imaging of Brain Pathophysiology BRAINPATH

Marie Curie Actions-Industry-Academia Partnerships and Pathways

Ultrafast Functional Ultrasound

Imaging for Highly-Resolved Targeted Mapping of Functional Connectivity

University Research Fund of Antwerp University BOF DOCPRO

Institute for the Promotion of Innovation by Science and Technology

Research Foundation Flanders

Publisher

Oxford University Press (OUP)

Subject

Cellular and Molecular Neuroscience,Cognitive Neuroscience

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