Sex-Dependent Effects of theAPOEɛ4 Allele on Behavioral Traits and White Matter Structures in Young Adults-Reference-Cited by-同舟云学术

Sex-Dependent Effects of theAPOEɛ4 Allele on Behavioral Traits and White Matter Structures in Young Adults

Published:2020-09-21 Issue:1 Volume:31 Page:672-680
ISSN:1047-3211
Container-title:Cerebral Cortex
language:en
Short-container-title:

Author:

Takeuchi Hikaru¹^ORCID,Tomita Hiroaki²³,Browne Ryan⁴,Taki Yasuyuki⁵⁶,Kikuchi Yoshie³,Ono Chiaki³,Yu Zhiqian³,Nouchi Rui⁴⁷⁸,Yokoyama Ryoichi⁹,Kotozaki Yuka¹⁰,Nakagawa Seishu¹¹¹²,Sekiguchi Atsushi⁵¹³,Iizuka Kunio²,Hanawa Sugiko¹¹,Araki Tsuyoshi¹⁴,Miyauchi Carlos Makoto⁴,Sakaki Kohei⁴,Nozawa Takayuki¹⁵,Ikeda Shigeyuki¹⁶,Yokota Susumu¹⁷,Magistro Daniele¹⁸,Sassa Yuko¹,Kawashima Ryuta¹⁴¹⁶

Affiliation:

1. Division of Developmental Cognitive Neuroscience, Institute of Development, Aging and Cancer, Tohoku University, Sendai 980-8575, Japan

2. Department of Psychiatry, Graduate School of Medicine, Tohoku University, Sendai 980-8575, Japan

3. Department of Disaster Psychiatry, International Research Institute of Disaster Science, Tohoku University, Sendai 980-8575, Japan

4. Department of Advanced Brain Science, Institute of Development, Aging and Cancer, Tohoku University, Sendai 980-8575, Japan

5. Division of Medical Neuroimaging Analysis, Department of Community Medical Supports, Tohoku Medical Megabank Organization, Tohoku University, Sendai 980-8575, Japan

6. Department of Radiology and Nuclear Medicine, Institute of Development, Aging and Cancer, Tohoku University, Sendai 980-8575, Japan

7. Department of Cognitive Health Science, IDAC, Tohoku University, Sendai 980-8575, Japan

8. Smart Aging Research Center, Tohoku University, Sendai 980-8575, Japan

9. School of Medicine, Kobe University, Kobe 650-0017, Japan

10. Division of Clinical research, Medical-Industry Translational Research Center, Fukushima Medical University School of Medicine, Fukushima 960-1925, Japan

11. Department of Human Brain Science, Institute of Development, Aging and Cancer, Tohoku University, Sendai 980-8575, Japan

12. Division of Psychiatry, Tohoku Medical and Pharmaceutical University, Sendai 983-8536, Japan

13. Department of Behavioral Medicine, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo 187-8553, Japan

14. ADVANTAGE Risk Management Co., Ltd. , Tokyo 153-0051, Japan

15. Research Institute for the Earth Inclusive Sensing, Tokyo Institute of Technology, Tokyo 152-8550, Japan

16. Department of Ubiquitous Sensing, Institute of Development, Aging and Cancer, Tohoku University, Sendai 980-8575, Japan

17. Division for Experimental Natural Science, Faculty of Arts and Science, Kyushu University, Fukuoka 819-0385, Japan

18. Department of Sport Science, School of Science and Technology, Nottingham Trent University, Nottingham NG11 8NS, UK

Abstract

AbstractThe APOE ɛ4 allele is associated with a risk of Alzheimer’s disease in the elderly, with the association being pronounced in females. Conversely, findings of the effects of the APOE ɛ4 allele in young adults are mixed. Here, we investigated the sex–genotype interaction effects of the APOE ɛ4 allele on cognitive functions as well as brain structures among 1258 young adults. After adjusting for multiple comparisons, there were significant effects of the interaction between sex and the number of APOE ɛ4 allele on some speed tasks (e.g., simple processing speed tasks and the reverse Stroop task) as well as on regional white matter volume (rWMV). The observed sex–genotype interaction conferred better cognitive performance and greater rWMV in the anterior frontal and precentral white matter areas in females having more APOE ɛ4 alleles and reduced rWMV in the same areas in male having more APOE ɛ4 alleles. These findings support the long-debated antagonistic pleiotropic effects of the APOE ɛ4 allele in females.

Funder

Young Scientists Fund

Ministry of Education, Culture, Sports, Science and Technology

Publisher

Oxford University Press (OUP)

Subject

Cellular and Molecular Neuroscience,Cognitive Neuroscience

Link

http://academic.oup.com/cercor/article-pdf/31/1/672/34840434/bhaa251.pdf

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