Sensory experience selectively reorganizes the late component of evoked responses

Author:

Bermudez-Contreras Edgar1ORCID,Schjetnan Andrea Gomez-Palacio2ORCID,Luczak Artur1ORCID,Mohajerani Majid H1ORCID

Affiliation:

1. Canadian Centre for Behavioral Neuroscience, University of Lethbridge , Lethbridge, AB T1K 3M4 , Canada

2. Krembil Neuroscience Center , Toronto, ON M5T OS8 , Canada

Abstract

Abstract In response to sensory stimulation, the cortex exhibits an early transient response followed by late and slower activation. Recent studies suggest that the early component represents features of the stimulus while the late component is associated with stimulus perception. Although very informative, these studies only focus on the amplitude of the evoked responses to study its relationship with sensory perception. In this work, we expand upon the study of how patterns of evoked and spontaneous activity are modified by experience at the mesoscale level using voltage and extracellular glutamate transient recordings over widespread regions of mouse dorsal neocortex. We find that repeated tactile or auditory stimulation selectively modifies the spatiotemporal patterns of cortical activity, mainly of the late evoked response in anesthetized mice injected with amphetamine and also in awake mice. This modification lasted up to 60 min and results in an increase in the amplitude of the late response after repeated stimulation and in an increase in the similarity between the spatiotemporal patterns of the late early evoked response. This similarity increase occurs only for the evoked responses of the sensory modality that received the repeated stimulation. Thus, this selective long-lasting spatiotemporal modification of the cortical activity patterns might provide evidence that evoked responses are a cortex-wide phenomenon. This work opens new questions about how perception-related cortical activity changes with sensory experience across the cortex.

Funder

Canadian Institutes of Health Research

Natural Sciences and Engineering Research Council of Canada

Alberta Innovates

Alberta Alzheimer Research Program

Alzheimer Society of Canada

Publisher

Oxford University Press (OUP)

Subject

Cellular and Molecular Neuroscience,Cognitive Neuroscience

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