Affiliation:
1. Shaanxi Key Laboratory of Brain Disorders, Institute of Basic and Translational Medicine, Xi’an Medical University , Xi’an , China
Abstract
Abstract
Senescent cells express and secrete a variety of extracellular modulators that include cytokines, chemokines, proteases, growth factors, and some enzymes associated with extracellular matrix remodeling, defined as the senescence-associated secretory phenotype (SASP). SASP reinforces senescent cell cycle arrest, stimulates and recruits immune cells for immune-mediated clearance of potentially tumorigenic cells, limits or induces fibrosis, and promotes wound healing and tissue regeneration. On the other hand, SASP mediates chronic inflammation leading to the destruction of tissue structure and function and stimulating the growth and survival of tumor cells. SASP is highly heterogeneous and the role of SASP depends on the context. The regulation of SASP occurs at multiple levels including chromatin remodeling, transcription, mRNA translation, intracellular trafficking, and secretion. Several SASP modulators have already been identified setting the stage for future research on their clinical applications. In this review, we summarize in detail the potential signaling pathways that trigger and regulate SASP production during aging and senescence.
Funder
National Natural Science Foundation of China
Special Scientific Research Plan of Shaanxi Provincial Education Department
Natural Science Basic Research Program of Shaanxi Province
Science Research of Xi’an Medical University
Young Talent Fund of University Association for Science and Technology in Shaanxi, China
Publisher
Oxford University Press (OUP)
Subject
Geriatrics and Gerontology,Aging
Cited by
23 articles.
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