Aging-Related Overactivity of the Angiotensin/AT1 Axis Decreases Sirtuin 3 Levels in the Substantia Nigra, Which Induces Vulnerability to Oxidative Stress and Neurodegeneration

Author:

Diaz-Ruiz Carmen1,Villar-Cheda Begoña1,Dominguez-Meijide Antonio1,Garrido-Gil Pablo1,Guerra Maria J1,Labandeira-Garcia Jose L

Affiliation:

1. Laboratory of Cellular and Molecular Neurobiology of Parkinson’s disease, Research Center for Molecular Medicine and Chronic Diseases (CIMUS), Faculty of Medicine, University of Santiago de Compostela, Networking Research Center on Neurodegenerative Diseases (CIBERNED), Spain

Funder

Spanish Ministry of Economy and Competitiveness

Spanish Ministry of Health

Galician Government

CIMUS

FEDER

Publisher

Oxford University Press (OUP)

Subject

Geriatrics and Gerontology,Aging

Reference50 articles.

1. Mammalian sirtuins: biological insights and disease relevance;Haigis;Annu Rev Pathol,2010

2. SIRT3 reverses aging-associated degeneration;Brown;Cell Rep,2013

3. Function of the SIRT3 mitochondrial deacetylase in cellular physiology, cancer, and neurodegenerative disease;Ansari;Aging Cell,2017

4. SIRT3 and mitochondrial metabolism in neurodegenerative diseases;Salvatori;Neurochem Int,2017

5. Differential expression of sirtuins in the aging rat brain;Braidy;Front Cell Neurosci,2015

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