First Observations of a Potential Association Between Accumulation of Per- and Polyfluoroalkyl Substances in the Central Nervous System and Markers of Alzheimer’s Disease

Author:

Delcourt Nicolas12ORCID,Pouget Alix-Marie1,Grivaud Alicia3,Nogueira Leonor4,Larvor Frédéric3,Marchand Philippe3,Schmidt Eric2,Le Bizec Bruno3

Affiliation:

1. Poison Control Center, Toulouse University Hospital , Toulouse , France

2. ToNIC, INSERM UMR1214 , Toulouse , France

3. LABERCA, Oniris, INRAE , Nantes , France

4. Toulouse University Hospital , 31059, Toulouse , France

Abstract

Abstract The entire human population is exposed to persistent organic pollutants throughout their lives. Among them, per- and polyfluoroalkyl substances (PFAS) are synthetic chemicals widely used in industrial and consumer products that are known to exert adverse effects on human health. As they bioaccumulate in the human brain and are known to be neurotoxic in experimental models, they are assumed to be involved in neurodegenerative processes. In this proof-of-concept study, we measured the level of 18 PFAS in cerebrospinal fluid (CSF) from 8 patients hospitalized with suspected normal pressure hydrocephalus. We then analyzed whether PFAS levels could be related to both biological and clinical markers of Alzheimer’s disease. We showed that PFAS and perfluorooctanesulfonate were found in all CSF samples from a French region without fluorochemical industries. Moreover, we observed a significant difference between the levels of PFAS and perfluorooctanesulfonate in the CSF of patients with both Alzheimer’s disease markers and cognitive impairment compared with those with only 1 or neither. Two previous studies have shown that PFAS levels in human CSF increase with age and are linked to impaired blood–brain barrier integrity. Our results provide the first evidence of a link between PFAS accumulation in the central nervous system and clinical and biological markers of Alzheimer’s disease.

Publisher

Oxford University Press (OUP)

Subject

Geriatrics and Gerontology,Aging

Reference40 articles.

1. A map of European emissions and concentrations of PFOS and PFOA;Pistocchi,2009

2. Scientific basis for managing PFAS as a chemical class;Kwiatkowski,2020

3. Per- and polyfluoroalkyl substances in the environment;Evich,2022

4. Worldwide trends in tracing poly- and perfluoroalkyl substances (PFAS) in the environment;Nakayama,2019

5. Occurrence of POPs and other persistent organic contaminants in the European eel (Anguilla anguilla) from the Loire estuary, France;Couderc,2015

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