Associations of Late-Life Sleep Medication Use With Incident Dementia in the Atherosclerosis Risk in Communities Study

Author:

Full Kelsie M1ORCID,Pusalavidyasagar Snigdha2,Palta Priya3,Sullivan Kevin J4ORCID,Shin Jung-Im5,Gottesman Rebecca F6,Spira Adam P789ORCID,Pase Matthew P10,Lutsey Pamela L1ORCID

Affiliation:

1. Division of Epidemiology and Community Health, University of Minnesota , Minneapolis, Minnesota , USA

2. Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, University of Minnesota , Minneapolis, Minnesota , USA

3. Division of General Medicine, Columbia University Irving Medical Center , New York, New York , USA

4. Department of Medicine, University of Mississippi Medical Center , Jackson, Mississippi , USA

5. Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health , Baltimore, Maryland, USA

6. Stroke Branch, National Institute of Neurological Disorders and Stroke Intramural Research Program , Bethesda, Maryland , USA

7. Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine , Baltimore, Maryland , USA

8. Department of Psychiatry and Behavioral Sciences, Johns Hopkins Center on Aging and Health , Baltimore, Maryland, USA

9. Department of Mental Health, Johns Hopkins Bloomberg School of Public Health , Baltimore, Maryland , USA

10. Turner Institute for Brain and Mental Health, Monash University , Clayton, Victoria , Australia

Abstract

Abstract Background Sleep medications may contribute to dementia development or indicate sleep disturbances that are markers of or contributors to neurologic disease. The objective of this study was to examine the use of sleep medications and incident dementia in a community-based cohort of older adults. We hypothesize late-life sleep medication use is associated with a greater risk of dementia. Methods The Atherosclerosis Risk in Communities (ARIC) study is an ongoing community-based cohort study. ARIC participants taking barbiturates, benzodiazepines, antidepressants, non-benzodiazepine receptor agonists (Z-drugs), or other hypnotics in 2011–2013 were categorized as sleep medication users. Participants were followed through 2019 for incident dementia. Logistic regression propensity scores were used to match sleep medication users with nonusers (1:2). Cox proportional hazards regression models were used to estimate hazard ratios (HR) for time to dementia diagnosis with adjustment for demographics, lifestyle characteristics, and cardiovascular risk factors. Results One-quarter of the eligible ARIC participants used sleep medications. In the matched sample (N = 4 197; 69% female; mean age 75.3 + 5.0 years), 632 dementia cases were ascertained over a median follow-up of 6.5 years. In the fully adjusted model, sleep medication use compared to nonuse was associated with a 48% greater risk of dementia (HR: 1.48; 95% confidence interval (CI): 1.26–1.74). Conclusion To expand on these findings, studies with longer follow-up and earlier assessment of sleep medication use are needed. Furthermore investigation of the potential dose-response association of multiple sleep medications and the potential causal role of sleep medications in the development of dementia may be clinically meaningful.

Funder

National Heart, Lung, and Blood Institute

National Institute on Deafness and Other Communication Disorders

National Institute of Neurological Disorders and Stroke

National Institute on Aging

National Institute of Diabetes and Digestive and Kidney Diseases

Publisher

Oxford University Press (OUP)

Subject

Geriatrics and Gerontology,Aging

Reference40 articles.

1. Dementia prevention, intervention, and care: 2020 report of the Lancet Commission;Livingston;Lancet.,2020

2. 2021 Alzheimer’s disease facts and figures;lzheimer’s Association;Alzheimer’s Dement.,2021

3. Gender and incidence of dementia in the Framingham Heart Study from mid-adult life;Chêne;Alzheimer’s Dement.,2015

4. Sleep duration, cognitive decline, and dementia risk in older women;Chen;Alzheimer’s Dement.,2016

5. Self-reported sleep disturbance and incidence of dementia in ageing men;Luojus;J Epidemiol Community Health.,2017

Cited by 9 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3