An Increase in Vascular Stiffness Is Positively Associated With Mitochondrial Bioenergetics Impairment of Peripheral Blood Mononuclear Cells in the Older Adults

Author:

Attachaipanich Tanawat12,Sriwichaiin Sirawit12,Apaijai Nattayaporn12,Kerdphoo Sasiwan12,Thongmung Nisakron3,Vathesatogkit Prin4,Sritara Piyamitr4,Chattipakorn Nipon125,Kitiyakara Chagriya4,Chattipakorn Siriporn C26ORCID

Affiliation:

1. Faculty of Medicine, Cardiac Electrophysiology Research and Training Center, Chiang Mai University , Chiang Mai , Thailand

2. Faculty of Medicine, Center of Excellence in Cardiac Electrophysiology Research, Chiang Mai University , Chiang Mai , Thailand

3. Office of Research Academic and Innovation, Faculty of Medicine Ramathibodi Hospital Mahidol University , Bangkok , Thailand

4. Department of Medicine, Faculty of Medicine Ramathibodi Hospital Mahidol University , Bangkok , Thailand

5. The Academy of Science, The Royal Society of Thailand , Bangkok

6. Department of Oral Biology and Diagnostic Sciences, Faculty of Dentistry, Chiang Mai University , Chiang Mai , Thailand

Abstract

Abstract The cardio-ankle vascular index (CAVI) is a noninvasive parameter reflecting vascular stiffness. CAVI correlates with the burden of atherosclerosis and future cardiovascular events. Mitochondria of peripheral blood mononuclear cells (PBMCs) have been identified as a noninvasive source for assessing systemic mitochondrial bioenergetics. This study aimed to investigate the relationship between CAVI values and mitochondrial bioenergetics of PBMCs in the older adults.. This cross-sectional study enrolled participants from the Electricity Generating Authority of Thailand between 2017 and 2018. A total of 1 640 participants with an ankle-brachial index greater than 0.9 were included in this study. All participants were stratified into 3 groups based on their CAVI values as high (CAVI ≥ 9), moderate (9 > CAVI ≥ 8), and low (CAVI < 8), in which each group comprised 702, 507, and 431 participants, respectively. The extracellular flux analyzer was used to measure mitochondrial respiration of isolated PBMCs. The mean age of the participants was 67.9 years, and 69.6% of them were male. After adjusted with potential confounders including age, sex, smoking status, body mass index, diabetes, dyslipidemia, hypertension, and creatinine clearance, participants with high CAVI values were independently associated with impaired mitochondrial bioenergetics, including decreased basal respiration, maximal respiration, and spare respiratory capacity, as well as increased mitochondrial reactive oxygen species. This study demonstrated that CAVI measurement reflects the underlying impairment of cellular mitochondrial bioenergetics in PBMCs. Further longitudinal studies are necessary to establish both a causal relationship between CAVI measurement and underlying cellular dysfunction.

Funder

National Research Council of Thailand

Chiang Mai University Center of Excellence Award

Faculty of Medicine, Ramathibodi Hospital, Mahidol University

Thailand Science Research and Innovation

Thai Heart Association

Thai Health Foundation

Higher Education Research Promotion and National Research University Development

Centro de Investigação em Ciências Sociais

Cooperative Research Network

Health Systems Research Institute

Publisher

Oxford University Press (OUP)

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