A Neuroscience Primer for Integrating Geroscience With the Neurobiology of Aging

Author:

Hernandez Caesar M12ORCID,Hernandez Abigail R23ORCID,Hoffman Jessica M3,King Peter H145,McMahon Lori L1267,Buford Thomas W23678,Carter Christy23ORCID,Bizon Jennifer L9,Burke Sara N9

Affiliation:

1. Department of Cellular, Development, and Integrative Biology, The University of Alabama at Birmingham, Birmingham, Alabama, USA

2. Evelyn F. McKnight Brain Institute, The University of Alabama at Birmingham, Birmingham, Alabama, USA

3. Department of Medicine, Division of Gerontology, Geriatrics, and Palliative Care, The University of Alabama at Birmingham, Birmingham, Alabama, USA

4. Department of Neurology, The University of Alabama at Birmingham, Birmingham, Alabama, USA

5. Birmingham Veterans Affairs Medical Center, Birmingham, Alabama, USA

6. UAB Nathan Shock Center for the Basic Biology of Aging, The University of Alabama at Birmingham, Birmingham, Alabama, USA

7. UAB Integrative Center for Aging Research, The University of Alabama at Birmingham, Birmingham, Alabama, USA

8. Geriatric Research Education and Clinical Center, Birmingham VA Medical Center, Birmingham, Alabama, USA

9. Department of Neuroscience, Center for Cognitive Aging and Memory, and the McKnight Brain Institute, The University of Florida, College of Medicine, Gainesville, Florida, USA

Abstract

Abstract Neuroscience has a rich history of studies focusing on neurobiology of aging. However, much of the aging studies in neuroscience occur outside of the gerosciences. The goal of this primer is 2-fold: first, to briefly highlight some of the history of aging neurobiology and second, to introduce to geroscientists the broad spectrum of methodological approaches neuroscientists use to study the neurobiology of aging. This primer is accompanied by a corresponding geroscience primer, as well as a perspective on the current challenges and triumphs of the current divide across these 2 fields. This series of manuscripts is intended to foster enhanced collaborations between neuroscientists and geroscientists with the intent of strengthening the field of cognitive aging through inclusion of parameters from both areas of expertise.

Funder

National Institutes of Health

National Institute of Child Health and Human Development

Evelyn F. McKnight Brain Research Foundation

NIH

National Institute on Aging

Publisher

Oxford University Press (OUP)

Subject

Geriatrics and Gerontology,Aging

Reference197 articles.

1. Cognitive effort: a neuroeconomic approach;Westbrook;Cogn Affect Behav Neurosci,2015

2. Reuniting the body “neck up and neck down” to understand cognitive aging: the nexus of geroscience and neuroscience;Hernandez;J Gerontol A Biol Sci Med Sci

3. Bridging the gap: A geroscience primer for neuroscientists with potential collaborative applications;Hoffman;J Gerontol A Biol Sci Med Sci,2021

4. Biometrical studies on man: I. Variation and correlation in brain-weight;Pearl;Biometrika,1905

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