The Health, Aging, and Body Composition (Health ABC) Study—Ground-Breaking Science for 25 Years and Counting-Reference-Cited by-同舟云学术

The Health, Aging, and Body Composition (Health ABC) Study—Ground-Breaking Science for 25 Years and Counting

Published:2023-07-11 Issue:11 Volume:78 Page:2024-2034
ISSN:1079-5006
Container-title:The Journals of Gerontology: Series A
language:en
Short-container-title:

Author:

Newman Anne B¹^ORCID,Visser Marjolein²^ORCID,Kritchevsky Stephen B³^ORCID,Simonsick Eleanor⁴^ORCID,Cawthon Peggy M⁵,Harris Tamara B⁶

Affiliation:

1. Department of Epidemiology, School of Public Health, University of Pittsburgh , Pittsburgh, Pennsylvania , USA

2. Department of Health Sciences, Faculty of Science, Vrije Universiteit Amsterdam , Amsterdam , The Netherlands

3. Department of Internal Medicine, Wake Forest University School of Medicine , Winston-Salem, North Carolina , USA

4. National Institute on Aging, Translational Gerontology Branch Biomedical Research Center , Baltimore, Maryland , USA

5. Research Institute, California Pacific Medical Center, University of California , San Francisco, California , USA

6. Laboratory of Epidemiology and Population Sciences, Intramural Research Program NIA, NIH , Bethesda, Maryland , USA

Abstract

Abstract Background The Health, Aging, and Body Composition Study is a longitudinal cohort study that started just over 25 years ago. This ground-breaking study tested specific hypotheses about the importance of weight, body composition, and weight-related health conditions for incident functional limitation in older adults. Methods Narrative review with analysis of ancillary studies, career awards, publications, and citations. Results Key findings of the study demonstrated the importance of body composition as a whole, both fat and lean mass, in the disablement pathway. The quality of the muscle in terms of its strength and its composition was found to be a critical feature in defining sarcopenia. Dietary patterns and especially protein intake, social factors, and cognition were found to be critical elements for functional limitation and disability. The study is highly cited and its assessments have been widely adopted in both observational studies and clinical trials. Its impact continues as a platform for collaboration and career development. Conclusions The Health ABC provides a knowledge base for the prevention of disability and promotion of mobility in older adults.

Funder

National Institute on Aging

National Institute of Arthritis and Musculoskeletal Disease and Skin Diseases

National Institute of Diabetes and Digestive and Kidney Diseases

National Center for Mental health Disorders

Centers for Disease Control and Prevention

Publisher

Oxford University Press (OUP)

Subject

Geriatrics and Gerontology,Aging

Link

https://academic.oup.com/biomedgerontology/advance-article-pdf/doi/10.1093/gerona/glad167/51039970/glad167.pdf

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