Understanding Longevity: SIN-3 and DAF-16 Revealed as Independent Players in Lifespan Regulation

Author:

Konwar Chandrika12,Maini Jayant3,Saluja Daman14

Affiliation:

1. Dr. B. R. Ambedkar Center for Biomedical Research, University of Delhi , Delhi , India

2. Biology and Bioengineering Division, Tianqiao and Chrissy Chen Institute of Neuroscience, California Institute of Technology , Pasadena, California , USA

3. Department of Biotechnology, School of Engineering and Technology, Manav Rachna International Institute of Research and Studies , Faridabad, Haryana , India

4. Delhi School of Public Health, IoE, University of Delhi , Delhi , India

Abstract

Abstract Aging is the process of gradual physio-biochemical deterioration. Although aging is inevitable, healthy aging is the key to individual and communal well-being. Therefore, it is essential to understand the regulation of aging. SIN-3/Sin-3 is a unique regulatory protein that regulates aging without DNA-binding activity. It functions by establishing multiple protein interactions. To understand the functional mechanism of this transcriptional regulator, the Caenorhabditis elegans protein interactome was assessed for SIN-3 interactions. DAF-16/FOXO emerged as one of the leading contenders for SIN-3-mediated regulation of aging. This study looks at the concerted role of SIN-3 and DAF-16 proteins in lifespan regulation. Phenotypic profiling for the mutants of these genes shows the functional accord between these 2 proteins with similar functions in stress response and vital biological processes. However, there were no significant physical interactions when checked for protein–protein interaction between SIN-3 and DAF-16 proteins. C. elegans genomics and transcriptomics data also indicated the possibilities of concerted gene regulation. This genetic regulation is more likely related to SIN-3 dominance on DAF-16 function. Overall, SIN-3 and DAF-16 proteins have strong functional interactions that ensure healthy aging. The influence of SIN-3 on DAF-16-mediated stress response is one of their convergence points in longevity regulation.

Publisher

Oxford University Press (OUP)

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