Significant Acceleration of Regional Brain Aging and Atrophy After Mild Traumatic Brain Injury

Author:

Shida Alexander F1ORCID,Massett Roy J1,Imms Phoebe1,Vegesna Ramanand V1,Amgalan Anar1,Irimia Andrei123ORCID

Affiliation:

1. Ethel Percy Andrus Gerontology Center, Leonard Davis School of Gerontology, University of Southern California , Los Angeles, California , USA

2. Corwin D. Denney Research Center, Department of Biomedical Engineering, Viterbi School of Engineering, University of Southern California , Los Angeles, California , USA

3. Department of Quantitative & Computational Biology, Dana and David Dornsife College of Arts & Sciences, University of Southern California , Los Angeles, California , USA

Abstract

Abstract Brain regions’ rates of age-related volumetric change after traumatic brain injury (TBI) are unknown. Here, we quantify these rates cross-sectionally in 113 persons with recent mild TBI (mTBI), whom we compare against 3 418 healthy controls (HCs). Regional gray matter (GM) volumes were extracted from magnetic resonance images. Linear regression yielded regional brain ages and the annualized average rates of regional GM volume loss. These results were compared across groups after accounting for sex and intracranial volume. In HCs, the steepest rates of volume loss were recorded in the nucleus accumbens, amygdala, and lateral orbital sulcus. In mTBI, approximately 80% of GM structures had significantly steeper rates of annual volume loss than in HCs. The largest group differences involved the short gyri of the insula and both the long gyrus and central sulcus of the insula. No significant sex differences were found in the mTBI group, regional brain ages being the oldest in prefrontal and temporal structures. Thus, mTBI involves significantly steeper regional GM loss rates than in HCs, reflecting older-than-expected regional brain ages.

Funder

National Institutes of Health

U.S. Department of Defense

Hanson-Thorell Family Research Scholarship

Alzheimer's Disease Neuroimaging Initiative

National Institute on Aging

National Institute of Biomedical Imaging and Bioengineering

Alzheimer's Association

Alzheimer's Drug Discovery Foundation

Janssen Alzheimer Immunotherapy Research And Development

Johnson and Johnson Pharmaceutical Research and Development

Neurotrack Technologies

Canadian Institutes of Health Research

National Institute of Neurological Disorders and Stroke

Publisher

Oxford University Press (OUP)

Subject

Geriatrics and Gerontology,Aging

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3