Biomarkers of Alzheimer’s Disease and Cerebrovascular Disease in Relation to Depressive Symptomatology in Individuals With Subjective Cognitive Decline

Author:

Zapater-Fajarí Mariola12ORCID,Diaz-Galvan Patricia13,Cedres Nira45ORCID,Rydberg Sterner Therese67,Rydén Lina67,Sacuiu Simona17,Waern Margda68,Zettergren Anna67,Zetterberg Henrik79ORCID,Blennow Kaj79,Kern Silke710,Hidalgo Vanesa211,Salvador Alicia212,Westman Eric113ORCID,Skoog Ingmar710,Ferreira Daniel15ORCID

Affiliation:

1. Division of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences, and Society, Karolinska Institute , Stockholm , Sweden

2. Laboratory of Cognitive Social Neuroscience, Department of Psychobiology and IDOCAL, University of Valencia , Valencia , Spain

3. Department of Radiology, Mayo Clinic , Rochester, Minnesota , USA

4. Department of Psychology, Sensory Cognitive Interaction Laboratory (SCI-Lab), Stockholm University , Stockholm , Sweden

5. Facultad de Ciencias de la Salud, Universidad Fernando Pessoa Canarias , Las Palmas de Gran Canaria, España

6. Centre for Ageing and Health at The University of Gothenburg , Gothenburg , Sweden

7. Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at The University of Gothenburg , Gothenburg , Sweden

8. Region Västra Götaland, Sahlgrenska University Hospital, Psychosis Department , Gothenburg , Sweden

9. Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital , Mölndal , Sweden

10. Region Västra Götaland, Sahlgrenska University Hospital, Clinic for Psychiatry, Cognition and Old Age Psychiatry , Gothenburg , Sweden

11. IIS Aragón, Department of Psychology and Sociology, Area of Psychobiology, University of Zaragoza , Teruel , Spain

12. Spanish National Network for Research in Mental Health CIBERSAM , Madrid , Spain

13. Department of Neuroimaging, Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, King’s College London , London , UK

Abstract

Abstract Background Subjective cognitive decline (SCD) has gained recent interest as a potential harbinger of neurodegenerative diseases such as Alzheimer’s disease (AD) and cerebrovascular disease (CVD). In addition, SCD can be related to depressive symptomatology. However, the association between AD and CVD biomarkers, depressive symptomatology, and SCD is still unclear. We investigated the association of AD and CVD biomarkers and depressive symptomatology with SCD in individuals with subjective memory complaints (SCD-memory group) and individuals with subjective concentration complaints (SCD-concentration group). Methods We recruited a population-based cohort of 217 individuals (all aged 70 years, 53% female participants, 119 SCD-memory individuals, 23 SCD-concentration individuals, and 89 controls). AD and CVD were assessed through cerebrospinal fluid levels of the Aβ42/40 ratio and phosphorylated tau, and white matter signal abnormalities on magnetic resonance imaging, respectively. Associations between biomarkers, depressive symptomatology, and SCD were tested via logistic regression and correlation analyses. Results We found a significant association between depressive symptomatology with SCD-memory and SCD-concentration. Depressive symptomatology was not associated with AD and CVD biomarkers. Both the phosphorylated tau biomarker and depressive symptomatology predicted SCD-memory, and the Aβ42/40 ratio and depressive symptomatology predicted SCD-concentration. Conclusions The role of depressive symptomatology in SCD may differ depending on the stage within the spectrum of preclinical AD (as determined by amyloid-beta and tau positivity), and does not seem to reflect AD pathology. Our findings contribute to the emerging field of subclinical depressive symptomatology in SCD and clarify the association of different types of subjective complaints with distinct syndromic and biomarker profiles.

Funder

Swedish Research Council

Swedish Research Council for Health, Working Life and Welfare

Konung Gustaf V:s och Drottning Victorias Frimurarestiftelse

Alzheimerfonden

Eivind och Elsa K:son Sylvans stiftelse

Center for Innovative Medicine

Gun och Bertil Stohnes Stiftelse, Demensfonden, Karolinska Institutet Forskningsstiftelser

Karolinska Institute for Geriatric Diseases

Spanish Science, Innovation and Universities Ministry

Swedish State Support for Clinical Research

Alzheimer Drug Discovery Foundation

AD Strategic Fund and the Alzheimer’s Association

Olav Thon Foundation, the Erling-Persson Family Foundation, Stiftelsen för Gamla Tjänarinnor

Marie Skłodowska-Curie

European Union Joint Programme—Neurodegenerative Disease Research

UK Dementia Research Institute at UCL

Psykiatriska Forskningsfonden

Stiftelsen Demensfonden

Stiftelsen Hjalmar Svenssons Forskningsfond

Stiftelsen Wilhelm och Martina Lundgrens vetenskapsfond

Alzheimer's Drug Discovery Foundation

Swedish Alzheimer Foundation

European Union Joint Program for Neurodegenerative Disorders

National Institute of Health

Alzheimer’s Association 2021 Zenith Award

Publisher

Oxford University Press (OUP)

Subject

Geriatrics and Gerontology,Aging

Reference50 articles.

1. A conceptual framework for research on subjective cognitive decline in preclinical Alzheimer’s disease;Jessen,2014

2. Subjective cognitive complaints and amyloid burden in cognitively normal older individuals;Amariglio,2012

3. Region-specific association of subjective cognitive decline with Tauopathy independent of global β-amyloid burden;Buckley,2017

4. Late-life depression and risk of vascular dementia and Alzheimer’s disease: systematic review and meta-analysis of community-based cohort studies;Diniz,2013

5. Subjective cognitive decline below and above the age of 60: a multivariate study on neuroimaging, cognitive, clinical, and demographic measures;Cedres,2019

Cited by 2 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3