Human Pineal Gland Involutionary Process: New Findings-Reference-Cited by-同舟云学术

Human Pineal Gland Involutionary Process: New Findings

Published:2023-03-26 Issue:9 Volume:78 Page:1558-1560
ISSN:1079-5006
Container-title:The Journals of Gerontology: Series A
language:en
Short-container-title:

Author:

Junemann Olga¹²^ORCID,Bukreeva Inna¹,Otlyga Dmitry A²,Cedola Alessia¹,Fratini Michela¹³,Saveliev Sergei V²

Affiliation:

1. Institute of Nanotechnology-CNR , Rome , Italy

2. Avtsyn Research Institute of Human Morphology of FSBSI, Petrovsky National Research Centre of Surgery , Moscow , Russian Federation

3. Santa Lucia Foundation , Rome , Italy

Abstract

Abstract In this work, we report preliminary results about the involution of the human pineal gland involution. The detailed analysis of pineal structure was done on autopsy material of 77 persons in age 27–96 using x-ray phase-contrast tomography, histology, and immunohistochemistry. Our study suggests that the pineal gland alteration in older adults may be more profound than has been reported to date. We identified and described a new form of pineal gland involution that eventually led to the total degradation of the pineal gland. To our knowledge, this study is the first to report on the complete replacement of pineal gland parenchyma with connective tissue in older adults.

Funder

MIUR/CNR

Regione Puglia

Publisher

Oxford University Press (OUP)

Subject

Geriatrics and Gerontology,Aging

Link

https://academic.oup.com/biomedgerontology/advance-article-pdf/doi/10.1093/gerona/glad091/50097670/glad091.pdf

Reference19 articles.

1. Raising awareness of sleep as a healthy behavior;Perry;Prev Chronic Dis.,2013

2. Meta-analysis of randomized, double-blind, placebo-controlled trials of melatonin in Alzheimer’s disease;Wang;Geriatr Psychiatry,2017

3. Sleep: a health imperative;Luyster;Sleep.,2012

4. Pineal gland and schizophrenia: a systematic review and meta-analysis;Bastos;Psychoneuroendocrinology.,2019