Calcium isotopes as a biomarker for vascular calcification in chronic kidney disease

Author:

Dosseto Anthony1,Lambert Kelly2,Cheikh Hassan Hicham I23,Fuller Andrew12,Borst Addison12,Dux Florian1,Lonergan Maureen3,Tacail Theo4ORCID

Affiliation:

1. Wollongong Isotope Geochronology Laboratory, School of Earth, Atmospheric and Life Sciences, University of Wollongong,   Wollongong , New South Wales, Australia

2. School of Medicine, University of Wollongong,   Wollongong , New South Wales, Australia

3. Department of Nephrology, Wollongong Hospital,   Wollongong , New South Wales, Australia

4. Institute of Geosciences, Johannes Gutenberg University , Mainz , Germany

Abstract

Abstract Calcium balance is abnormal in adults with chronic kidney disease (CKD) and is associated with the development of vascular calcification. It is currently not routine to screen for vascular calcification in CKD patients. In this cross-sectional study, we investigate whether the ratio of naturally occurring calcium (Ca) isotopes, 44Ca and 42Ca, in serum could be used as a noninvasive marker of vascular calcification in CKD. We recruited 78 participants from a tertiary hospital renal center: 28 controls, 9 subjects with mild–moderate CKD, 22 undertaking dialysis and 19 who received a kidney transplant. For each participant, systolic blood pressure, ankle brachial index, pulse wave velocity, and estimated glomerular filtration rate were measured, along with serum markers. Calcium concentrations and isotope ratios were measured in urine and serum. While we found no significant association between urine Ca isotope composition (noted δ44/42Ca) between the different groups, δ44/42Ca values in serum were significantly different between healthy controls, subjects with mild–moderate CKD and those undertaking dialysis (P < 0.01). Receiver operative characteristic curve analysis shows that the diagnostic utility of serum δ44/42Ca for detecting medial artery calcification is very good (AUC = 0.818, sensitivity 81.8% and specificity 77.3%, P < 0.01), and performs better than existing biomarkers. Although our results will need to be verified in prospective studies across different institutions, serum δ44/42Ca has the potential to be used as an early screening test for vascular calcification.

Funder

Univeristy of Wollongong

Publisher

Oxford University Press (OUP)

Subject

Metals and Alloys,Biochemistry,Biomaterials,Biophysics,Chemistry (miscellaneous)

Reference37 articles.

1. Global, Regional, and National Burden of Chronic Kidney Disease, 1990-2017: a Systematic Analysis for the Global Burden of Disease Study 2017;Collaboration GBDCKD,2020

2. Cardiovascular Disease in Chronic Kidney Disease;Jankowski;Circulation,2021

3. Vascular Calcification in Chronic Kidney Disease: Role of Disordered Mineral Metabolism;Palit;Curr. Pharm. Des.,2014

4. Current and Potential Therapeutic Strategies for the Management of Vascular Calcification in Patients with Chronic Kidney Disease Including Those on Dialysis;Ruderman;Semin. Dial.,2018

5. Should Nephrologists Consider Vascular Calcification Screening?;Krishnasamy;Nephrology,2017

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3