Eradication of a Multidrug-Resistant, Carbapenemase-Producing Klebsiella pneumoniae Isolate Following Oral and Intra-rectal Therapy With a Custom Made, Lytic Bacteriophage Preparation-Reference-Cited by-同舟云学术

Eradication of a Multidrug-Resistant, Carbapenemase-Producing Klebsiella pneumoniae Isolate Following Oral and Intra-rectal Therapy With a Custom Made, Lytic Bacteriophage Preparation

Published:2019-08-15 Issue:9 Volume:70 Page:1998-2001
ISSN:1058-4838
Container-title:Clinical Infectious Diseases
language:en
Short-container-title:

Author:

Corbellino Mario¹^ORCID,Kieffer Nicolas²,Kutateladze Mzia³,Balarjishvili Nana³,Leshkasheli Lika³,Askilashvili Lia³,Tsertsvadze George³,Rimoldi Sara Giordana⁴,Nizharadze Deia⁵,Hoyle Naomi⁵,Nadareishvili Lia⁵,Antinori Spinello¹⁶,Pagani Cristina⁴,Scorza Daniele Giuseppe⁴,Romanò Ai Ling Loredana⁷,Ardizzone Sandro⁶⁸,Danelli Piergiorgio⁶⁹,Gismondo Maria Rita⁴⁶,Galli Massimo¹⁶,Nordmann Patrice²,Poirel Laurent²

Affiliation:

1. III Division of Infectious Diseases, Azienda Socio Sanitaria Territoriale (ASST) Fatebenefratelli Sacco, Milano, Italy

2. Medical and Molecular Microbiology, Faculty of Science and Medicine, Institut National de la Santé et de la Recherche Médicale (INSERM) European Unit (IAME, France), University of Fribourg, Fribourg, Switzerland

3. G. Eliava Institute of Bacteriophages, Microbiology and Virology, Tbilisi, Georgia

4. Division of Microbiology, ASST Fatebenefratelli–Sacco, Milano, Italy

5. Eliava Phage Therapy Center LLC, Tbilisi, Georgia

6. Luigi Sacco Department of Clinical and Biomedical Sciences, University of Milano, Milano, Italy

7. Division of Urology, ASST Fatebenefratelli - Sacco, Milano, Italy

8. Division of Gastroenterology, ASST Fatebenefratelli - Sacco, Milano, Italy

9. Division of General Surgery, ASST Fatebenefratelli - Sacco, Milano, Italy

Abstract

Abstract In July 2017, a patient presented colonization with a multidrug-resistant, carbapenemase (KPC-3)-producing Klebsiella pneumoniae isolate. A custom-made, lytic bacteriophage preparation was administered to the patient in December 2017, with subsequent eradication of the microorganism and without adverse effects.

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Microbiology (medical)

Link

http://academic.oup.com/cid/advance-article-pdf/doi/10.1093/cid/ciz782/30257254/ciz782.pdf

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