1. Department of Medicine and Research Center, Montreal Heart Institute and Université de Montréal, 5000 Belanger Street E, Montreal, QC H1T 1C8, Canada;
2. Department of Pharmacology and Therapeutics, McGill University Montreal, QC, Canada;
3. Institute of Pharmacology, West German Heart and Vascular Center, Faculty of Medicine, University Duisburg-Essen, Essen, Germany