The MEF2 transcriptional target DMPK induces loss of sarcomere structure and cardiomyopathy

Author:

Damanafshan Amin1,Elzenaar Ies1,Samson-Couterie Benoit1,van der Made Ingeborg1,Bourajjaj Meriem2,van den Hoogenhof Maarten M1,van Veen Henk A3,Picavet Daisy I3,Beqqali Abdelaziz1,Ehler Elisabeth4,De Windt Leon J2,Pinto Yigal M1,van Oort Ralph J1

Affiliation:

1. Department of Experimental Cardiology, Amsterdam Cardiovascular Sciences, Academic Medical Center, Amsterdam, The Netherlands

2. Department of Cardiology, Maastricht University, Maastricht, The Netherlands

3. Department of Medical Biology, Electron Microscopy Centre Amsterdam, Academic Medical Center, Amsterdam, The Netherlands

4. Cardiovascular Division, King’s College, London, UK

Funder

Medical Research Council and the British Heart Foundation

Dutch Heart Foundation

Dutch Federation of University Medical Centers

Netherlands Organization for Health Research and Development

Royal Netherlands Academy of Sciences

European Research Council

ERC

Netherlands Organization for Scientific Research

NWO

NHS

Publisher

Oxford University Press (OUP)

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

Reference41 articles.

1. Structural remodeling and mechanical dysfunction of cardiac myocytes in heart failure;Gerdes;J Mol Cell Cardiol,1995

2. Impairment of the myocardial ultrastructure and changes of the cytoskeleton in dilated cardiomyopathy;Schaper;Circulation,1991

3. Altered expression of titin and contractile proteins in failing human myocardium;Hein;J Mol Cell Cardiol,1994

4. MEF2 activates a genetic program promoting chamber dilation and contractile dysfunction in calcineurin-induced heart failure;van Oort;Circulation,2006

5. Myocyte enhancer factors 2A and 2C induce dilated cardiomyopathy in transgenic mice;Xu;J Biol Chem,2006

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