Recent developments in genetics and medically-assisted reproduction: from research to clinical applications†‡-Reference-Cited by-同舟云学术

Recent developments in genetics and medically-assisted reproduction: from research to clinical applications†‡

Published:2017 Issue:3 Volume:2017 Page:
ISSN:2399-3529
Container-title:Human Reproduction Open
language:en
Short-container-title:

Author:

Harper J C¹,Aittomäki K²,Borry P³,Cornel M C⁴,de Wert G⁵,Dondorp W⁵,Geraedts J⁶,Gianaroli L⁷,Ketterson K⁸,Liebaers I⁹¹⁰,Lundin K¹¹,Mertes H¹²,Morris M¹³,Pennings G¹²,Sermon K¹⁰,Spits C¹⁰,Soini S¹⁴,van Montfoort A P A¹⁵,Veiga A¹⁶¹⁷,Vermeesch J R¹⁸,Viville S¹⁹²⁰,Macek M²¹,

Affiliation:

1. Institute for Women's Health, University College London, 86-96 Chenies Mews, London WC1E 6HX, UK

2. Laboratory of Genetics, Helsinki University Hospital, PO Box 720, FI-00029, Helsinki, Finland

3. Department of Public Health and Primary Care, Centre for Biomedical Ethics and Law, KU Leuven, Kapucijnenvoer 35 - Box 7001. B-3000, Leuven Belgium

4. Department of Clinical Genetics, Amsterdam Public Health Research Institute, VU University Medical Center, PO Box 7057, 1007 MB, Amsterdam, The Netherlands

5. Department of Health, Ethics and Society, Research Schools CAPHRI and GROW, Maastricht University, De Byeplein 1, 6229 HA Maastricht, The Netherlands

6. Department Genetics and Cell Biology, GROW School for Oncology and Developmental Biology, Maastricht University Medical Center, P.O. Box 616, 6200 MD Maastricht, The Netherlands

7. S.I.S.Me.R. Reproductive Medicine Unit, Via Mazzini 12, 40138 Bologna, Italy

8. Althea Science, Inc., 3 Regent St #301, Livingston, NJ 07039, USA

9. Centre for Medical Genetics, UZ Brussel, Laarbeeklaan 101, B-1090 Brussels, Belgium

10. Research Group Reproduction and Genetics, Vrije Universiteit Brussel, Laarbeeklaan 101, B-1090, Brussels, Belgium

11. Reproductive Medicine, Sahlgrenska University Hospital, Blå Stråket 6, 413 45, Göteborg, Sweden

12. Bioethics Institute Ghent, Department of Philosophy and Moral Science, Ghent University, Belgium

13. Synlab Genetics, chemin d'Entre-Bois 21, CH-1018, Lausanne, Switzerland

14. Helsinki Biobank, Helsinki University Central Hospital, Haartmaninkatu 3, PO Box 400, 00029 HUS, Helsinki, Finland

15. IVF laboratory, Department of Obstetrics and Gynaecology, Maastricht University Medical Center, PO Box 5800, 6202 AZ Maastricht, The Netherlands

16. Barcelona Stem Cell Bank, Centre of Regenerative Medicine in Barcelona, Hospital Duran i Reynals, Gran Via de l' Hospitalet 199, 08908, Hospitalet de Llobregat, Barcelona, Spain

17. Reproductive Medicine Service of Dexeus Woman Health, Gran Via Carles III, 71-75 - 08028 Barcelona, Spain

18. Department of Human Genetics, KU Leuven, O&N I Herestraat 49 - Box 602, B-3000 Leuven, Belgium

19. Institute of Parasitology and Pathology, University of Strasbourg, 3 rue Koberlé, 67000 Strasbourg, France

20. Laboratory of Genetic Diagnostics, UF3472-Genetics of Infertility, Nouvel Hôpital Civil, 1 place de l'Hôpital, 67091 Strasbourg cedex, France

21. Department of Biology and Medical Genetics, Charles University 2nd Faculty of Medicine and Motol University Hospital, V Úvalu 84, Prague CZ-15006, Czech Republic

Abstract

Abstract Two leading European professional societies, the European Society of Human Genetics and the European Society for Human Reproduction and Embryology, have worked together since 2004 to evaluate the impact of fast research advances at the interface of assisted reproduction and genetics, including their application into clinical practice. In September 2016, the expert panel met for the third time. The topics discussed highlighted important issues covering the impacts of expanded carrier screening, direct-to-consumer genetic testing, voiding of the presumed anonymity of gamete donors by advanced genetic testing, advances in the research of genetic causes underlying male and female infertility, utilisation of massively-parallel sequencing in preimplantation genetic testing and non-invasive prenatal screening, mitochondrial replacement in human oocytes, and additionally, issues related to cross-generational epigenetic inheritance following IVF and germline genome editing. The resulting paper represents a consensus of both professional societies involved.

Funder

ESHRE

ESHG

Publisher

Oxford University Press (OUP)

Subject

Industrial and Manufacturing Engineering,Environmental Engineering

Link

http://academic.oup.com/hropen/article-pdf/2017/3/hox015/29018015/hox015.pdf

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