Depression and the Diagnosis of MCI in a Culturally Diverse Sample in the United States

Author:

Lang Merike1,Rosselli Mónica12,Greig Maria T23,Torres Valeria L1,Vélez-Uribe Idaly1,Arruda Fernanda1,Barker Warren W23,Garcia Patricia23,Loewenstein David A24,Curiel Rosie E24,Duara Ranjan23

Affiliation:

1. Department of Psychology, Florida Atlantic University, Davie, FL, USA

2. Florida Alzheimer’s Disease Research Center, Miami Beach, FL, USA

3. Wien Center for Alzheimer’s Disease and Memory Disorders, Mount Sinai Medical Center, Miami Beach, FL, USA

4. Center for Cognitive Neuroscience and Aging and the Department of Psychiatry & Behavioral Sciences, Miller School of Medicine, University of Miami, Miami, FL, USA

Abstract

Abstract Objective To analyze (1) whether there are ethnic differences in the severity of depressive symptoms between groups of elders classified as cognitively normal (CN) or amnestic mild cognitive impairment (aMCI) and (2) the influence of depressive symptoms on specific cognitive performance by ethnicity across diagnoses, controlling for covariates. Methods 164 Hispanics residing in the United States (HAs) and European Americans (EAs) (100 women; Mage = 72.1, SD = 8.0) were diagnosed as either CN or aMCI. Depressive symptoms were measured with the Geriatric Depression Scale (GDS-15). Cognition was assessed using the Loewenstein-Acevedo Scales for Semantic Interference and Learning (semantic memory), Multilingual Naming Test (confrontation naming), and the Stroop Test (Color–Word condition; executive function). A 2 × 2 univariate ANCOVA as well as linear and logistic regressions explored differences in depressive symptoms among diagnostic and ethnic groups. Results Higher depression was seen in aMCI compared to the CN group for both ethnicities, after controlling for age, education, gender, and Mini-Mental State Examination score. Greater levels of depression also predicted lower scores in confrontation naming and semantic memory for only the EA group and marginally in scores of executive function for HA participants. GDS-15 scores of ≤ 4 also predicted less likelihood of aMCI diagnosis. Conclusions Severity of depressive symptoms was associated with greater cognitive impairment, independent of ethnicity. Significant results suggest detrimental effects of depression on clinical diagnoses most evidently for subjects from the EA group.

Funder

National Institute on Aging

Publisher

Oxford University Press (OUP)

Subject

Psychiatry and Mental health,Clinical Psychology,Neuropsychology and Physiological Psychology,General Medicine

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