GSK3β-SCFFBXW7α mediated phosphorylation and ubiquitination of IRF1 are required for its transcription-dependent turnover
Author:
Affiliation:
1. School of Pharmacy, University of Nottingham, University Park, Nottingham, UK
2. Institute of Cancer & Genomic Sciences, University of Birmingham, Edgbaston, UK
Funder
Cancer Research UK
Biotechnology and Biological Sciences Research Council
Breast Cancer Campaign
Wellcome Trust
School of Pharmacy
Publisher
Oxford University Press (OUP)
Subject
Genetics
Link
http://academic.oup.com/nar/article-pdf/47/9/4476/28603201/gkz163.pdf
Reference41 articles.
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2. Tumor suppressor IRF-1 mediates retinoid and interferon anticancer signaling to death ligand TRAIL;Clarke;EMBO J.,2004
3. Regulation of immunity and oncogenesis by the IRF transcription factor family;Savitsky;Cancer Immunol. Immunother.,2010
4. Interferon regulatory factor 1 inactivation in human cancer;Alsamman;Biosci. Rep.,2018
5. A ChIPchip approach reveals a novel role for transcription factor IRF1 in the DNA damage response;Frontini;Nucleic Acids Res.,2009
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