Splice-Break: exploiting an RNA-seq splice junction algorithm to discover mitochondrial DNA deletion breakpoints and analyses of psychiatric disorders

Author:

Hjelm Brooke E12ORCID,Rollins Brandi1,Morgan Ling1,Sequeira Adolfo1,Mamdani Firoza1,Pereira Filipe3ORCID,Damas Joana4,Webb Michelle G2,Weber Matthieu D1,Schatzberg Alan F5,Barchas Jack D6,Lee Francis S6,Akil Huda7,Watson Stanley J7,Myers Richard M8,Chao Elizabeth C9,Kimonis Virginia9,Thompson Peter M10,Bunney William E1,Vawter Marquis P1

Affiliation:

1. Department of Psychiatry and Human Behavior, University of California-Irvine (UCI), Irvine, CA 92697, USA

2. Department of Translational Genomics, Keck School of Medicine of USC, University of Southern California (USC), Los Angeles, CA 90033, USA

3. Interdisciplinary Centre of Marine and Environmental Research (CIIMAR), University of Porto, Matosinhos 4050-123, Portugal

4. The Genome Center, University of California-Davis, Davis, CA 95616, USA

5. Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305, USA

6. Department of Psychiatry, Weill Cornell Medical College at Cornell University, New York, NY 10065, USA

7. The Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, MI 48109, USA

8. HudsonAlpha Institute for Biotechnology, Huntsville, AL 35806, USA

9. Division of Genetics and Genomic Medicine, Department of Pediatrics, UCI, Irvine, CA, USA

10. Southwest Brain Bank, Department of Psychiatry, Texas Tech University Health Sciences Center (TTUHSC), El Paso, TX 79905, USA

Funder

National Institute of Mental Health (NIMH), National Institutes of Health

Portuguese Foundation for Science and Technology

Publisher

Oxford University Press (OUP)

Subject

Genetics

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