Pathology Principles and Practices for Analysis of Animal Models

Author:

Knoblaugh Sue E1ORCID,Hohl Tobias M2,La Perle Krista M D1

Affiliation:

1. Department of Veterinary Biosciences, and Comparative Pathology & Mouse Phenotyping Shared Resource, The Ohio State University, Columbus, Ohio

2. Infectious Diseases Service, Memorial Sloan Kettering Cancer Center, New York City, New York

Abstract

Abstract Over 60% of NIH extramural funding involves animal models, and approximately 80% to 90% of these are mouse models of human disease. It is critical to translational research that animal models are accurately characterized and validated as models of human disease. Pathology analysis, including histopathology, is essential to animal model studies by providing morphologic context to in vivo, molecular, and biochemical data; however, there are many considerations when incorporating pathology endpoints into an animal study. Mice, and in particular genetically modified models, present unique considerations because these modifications are affected by background strain genetics, husbandry, and experimental conditions. Comparative pathologists recognize normal pathobiology and unique phenotypes that animals, including genetically modified models, may present. Beyond pathology, comparative pathologists with research experience offer expertise in animal model development, experimental design, optimal specimen collection and handling, data interpretation, and reporting. Critical pathology considerations in the design and use of translational studies involving animals are discussed, with an emphasis on mouse models.

Funder

NIH

Publisher

Oxford University Press (OUP)

Subject

General Biochemistry, Genetics and Molecular Biology,Animal Science and Zoology,General Medicine

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