Exome-wide association study reveals novel psoriasis susceptibility locus at TNFSF15 and rare protective alleles in genes contributing to type I IFN signalling

Author:

Dand Nick1ORCID,Mucha Sören2,Tsoi Lam C345,Mahil Satveer K6,Stuart Philip E3,Arnold Andreas7,Baurecht Hansjörg8,Burden A David9,Callis Duffin Kristina10,Chandran Vinod11121314,Curtis Charles J1516,Das Sayantan5,Ellinghaus David2,Ellinghaus Eva2,Enerback Charlotta17,Esko Tõnu18,Gladman Dafna D111314,Griffiths Christopher E M19,Gudjonsson Johann E3,Hoffman Per2021,Homuth Georg22,Hüffmeier Ulrike23,Krueger Gerald G10,Laudes Matthias24,Lee Sang Hyuck1516,Lieb Wolfgang25,Lim Henry W26,Löhr Sabine23,Mrowietz Ulrich8,Müller-Nurayid Martina27,Nöthen Markus21,Peters Annette27,Rahman Proton28,Reis André23,Reynolds Nick J2930,Rodriguez Elke8,Schmidt Carsten O31,Spain Sarah L1,Strauch Konstantin27,Tejasvi Trilokraj3,Voorhees John J3,Warren Richard B32,Weichenthal Michael33,Weidinger Stephan8,Zawistowski Matthew5,Nair Rajan P3,Capon Francesca1,Smith Catherine H6,Trembath Richard C1,Abecasis Goncalo R5,Elder James T334,Franke Andre2,Simpson Michael A1,Barker Jonathan N6

Affiliation:

1. Division of Genetics and Molecular Medicine, Faculty of Life Sciences & Medicine, King's College London, London, UK

2. Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany

3. Department of Dermatology

4. Department of Computational Medicine & Bioinformatics, University of Michigan Medical School, Ann Arbor, MI, USA

5. Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI, USA

6. St John's Institute of Dermatology, Faculty of Life Sciences & Medicine, King's College London, London, UK

7. Clinic and Polyclinic of Dermatology, University Medicine Greifswald, Greifswald, Germany

8. Department of Dermatology, Venereology and Allergy, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany

9. Institute of Infection, Inflammation and Immunity, University of Glasgow, Glasgow, UK

10. Department of Dermatology, University of Utah, Salt Lake City, UT, USA

11. Department of Medicine

12. Department of Laboratory Medicine and Pathobiology

13. Institute of Medical Science, University of Toronto, Toronto, ON, Canada

14. Krembil Research Institute, University Health Network, Toronto, ON, Canada

15. NIHR Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King’s College London, London, UK

16. Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK

17. Division of Cell Biology and Dermatology, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden

18. Estonian Biobank, Estonian Genome Center, University of Tartu, Tartu, Estonia

19. Dermatology Centre, Salford Royal Hospital, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK

20. Genomics Research Group, Department of Biomedicine, University of Basel, Basel, Switzerland

21. Institute of Human Genetics, University of Bonn, Bonn, Germany

22. Department of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine and Ernst-Moritz-Arndt-University Greifswald, Greifswald, Germany

23. Institute of Human Genetics, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany

24. I. Department of Medicine

25. Institute of Epidemiology and Biobank PopGen, Christian-Albrechts-University of Kiel, Kiel, Germany

26. Department of Dermatology, Henry Ford Hospital, Detroit, MI, USA

27. Institute of Genetic Epidemiology, Helmholtz Zentrum Munich, Neuherberg, Germany

28. Memorial University of Newfoundland, St. John's, NL, Canada

29. Dermatological Sciences, Institute of Cellular Medicine, Newcastle University Medical School, Newcastle upon Tyne, UK

30. Department of Dermatology, Royal Victoria Infirmary, Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK

31. Institute for Community Medicine, Study of Health in Pomerania/KEF, University Medicine Greifswald, Greifswald, Germany

32. Dermatology Centre, Salford Road NHS Foundation Trust, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK

33. Department of Dermatology, University Medical Center Schleswig-Holstein, Campus Kiel, Kiel, Germany

34. Ann Arbor Veterans Hospital, Ann Arbor, MI, USA

Funder

Maudsley Charity

MRC

Wellcome Trust

National Institutes of Health

Publisher

Oxford University Press (OUP)

Subject

Genetics(clinical),Genetics,Molecular Biology,General Medicine

Reference75 articles.

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