Two cases of systemic lupus erythematosus after administration of severe acute respiratory syndrome coronavirus 2 vaccine

Author:

Sakai Mayu1,Takao Ken1,Mizuno Masami1,Ando Hironori1,Kawashima Yui1,Kato Takehiro1,Kubota Saki12,Hirose Tokuyuki1,Hirota Takuo1,Horikawa Yukio1,Yabe Daisuke1234

Affiliation:

1. Department of Diabetes, Endocrinology and Metabolism/Department of Rheumatology and Clinical Immunology, Gifu University Graduate School of Medicine , Gifu, Japan

2. Yutaka Seino Distinguished Center for Diabetes Research, Kansai Electric Power Medical Research Institute , Kyoto, Japan

3. Center for One Medicine Innovative Translational Research, Gifu University Institute for Advanced Study , Gifu, Japan

4. Center for Healthcare Information Technology, Tokai National Higher Education and Research System , Nagoya, Japan

Abstract

ABSTRACT Although there is a great demand for increased coronavirus disease 2019vaccination worldwide, rare side effects of the vaccines in susceptible individuals are attracting attention. We recently treated two patients who developed systemic lupus erythematosus after administration of a severe acute respiratory syndrome coronavirus 2 vaccine from Pfizer-BioNTech or Moderna. While causal relationships between vaccination and adverse events are difficult to discern due to both confounding and masking factors, our findings suggest that attention to possible adjuvant-related autoimmune diseases in certain individuals receiving severe acute respiratory syndrome coronavirus 2 vaccines is appropriate.

Publisher

Oxford University Press (OUP)

Subject

Rheumatology

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