A proposed method of grading malaria chemoprevention efficacy

Author:

White N J12,Bonnington C23,Nosten F H24

Affiliation:

1. Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University , Bangkok 10400 , Thailand

2. Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford , OX3 7LJ , UK

3. Malaria Consortium , London , UK

4. Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University , Bangkok 10400 , Thailand

Abstract

ABSTRACT The efficacy and effectiveness of antimalarial drugs are threatened by increasing levels of resistance and therefore require continuous monitoring. Chemoprevention is increasingly deployed as a malaria control measure, but there are no generally accepted methods of assessment. We propose a simple method of grading the parasitological response to chemoprevention (focusing on seasonal malaria chemoprevention) that is based on pharmacometric assessment.

Funder

Wellcome Trust

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Public Health, Environmental and Occupational Health,General Medicine,Parasitology

Reference17 articles.

1. Estimating the potential public health impact of seasonal malaria chemoprevention in African children;Cairns;Nat Commun,2012

2. Two strategies for the delivery of IPTc in an area of seasonal malaria transmission in the Gambia: a randomised controlled trial;Bojang;PLoS Med,2011

3. Updated WHO recommendations for malaria chemoprevention among children and pregnant women

4. Consolidated guidelines for malaria;World Health Organization

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