Affiliation:
1. Laboratório de Fisiologia de Insetos Hematófagos, Departamento de Parasitologia—ICB, Universidade Federal de Minas Gerais—UFMG, Belo Horizonte, MG, Brazil
Abstract
Abstract
Lutzomyia longipalpis (Lutz & Neiva, 1912) females have been intensively studied regarding the regulation of midgut pH. The mechanisms involved in pH regulation are complex, and some aspects remain to be clarified. Here, we investigated the role of the Na+/K+-ATPase pump as an electrochemical potential generator and its modulation by the second messenger cAMP in the midgut of female L. longipalpis. Our results suggest that not only may Na+/K+-ATPase be the main generator of an electrochemical potential across membranes in the midgut of female L. longipalpis, but also its activity is positively regulated by cAMP. cAMP-mediated Na+/K+-ATPase pump activity might be necessary to maintain the transport of the nutrients produced during blood digestion.
Funder
Fundação de Amparo à Pesquisa do Estado de Minas Gerais
Conselho Nacional de Desenvolvimento Cientıfico e Tecnológico
Instituto Nacional de Ciência e Tecnologia—Entomologia Molecular
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
Publisher
Oxford University Press (OUP)
Subject
Insect Science,General Medicine
Cited by
2 articles.
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