Gender differences in patient experience in idiopathic inflammatory myopathies: Subanalysis from the COVAD dataset-Reference-Cited by-同舟云学术

Gender differences in patient experience in idiopathic inflammatory myopathies: Subanalysis from the COVAD dataset

Published:2023-09-28 Issue: Volume: Page:
ISSN:1439-7595
Container-title:Modern Rheumatology
language:en
Short-container-title:

Author:

Yoshida Akira¹^ORCID,Kim Minchul²,Kuwana Masataka¹,Ravichandran Naveen³,Makol Ashima⁴,Sen Parikshit⁵,Lilleker James B⁶⁷,Agarwal Vishwesh⁸,Kardes Sinan⁹,Day Jessica¹⁰¹¹¹²,Milchert Marcin¹³,Joshi Mrudula¹⁴,Gheita Tamer¹⁵,Salim Babur¹⁶,Velikova Tsvetelina¹⁷,Gracia-Ramos Abraham Edgar¹⁸,Parodis Ioannis¹⁹²⁰,Nikiphorou Elena²¹²²,Chatterjee Tulika²,Tan Ai Lyn²³²⁴,Nune Arvind²⁵,Cavagna Lorenzo²⁶²⁷,Saavedra Miguel A²⁸,Shinjo Samuel Katsuyuki²⁹,Ziade Nelly³⁰³¹,Knitza Johannes³²,Distler Oliver³³,Chinoy Hector³⁴³⁵³⁶,Agarwal Vikas⁴,Aggarwal Rohit³⁷,Gupta Latika⁴³⁴³⁸³⁹^ORCID

Affiliation:

1. Department of Allergy and Rheumatology, Nippon Medical School Graduate School of Medicine , Tokyo, Japan

2. Center for Outcomes Research, Department of Internal Medicine, University of Illinois College of Medicine Peoria , Peoria, IL, USA

3. Department of Clinical Immunology and Rheumatology, Sanjay Gandhi Postgraduate Institute of Medical Sciences , Lucknow, India

4. Division of Rheumatology, Mayo Clinic , Rochester, MN, USA

5. Maulana Azad Medical College , New Delhi, India

6. Centre for Musculoskeletal Research, Division of Musculoskeletal and Dermatological Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester , Manchester, UK

7. Neurology, Manchester Centre for Clinical Neurosciences, Northern Care Alliance NHS Foundation Trust , Salford, UK

8. Mahatma Gandhi Mission Medical College , Navi Mumbai, India

9. Department of Medical Ecology and Hydroclimatology, Istanbul Faculty of Medicine, Istanbul University , Capa-Fatih, Turkey

10. Department of Rheumatology , Royal Melbourne Hospital, Parkville, Australia

11. Walter and Eliza Hall Institute of Medical Research , Parkville, Australia

12. Department of Medical Biology, University of Melbourne , Parkville, Australia

13. Department of Internal Medicine, Rheumatology, Diabetology, Geriatrics and Clinical Immunology, Pomeranian Medical University in Szczecin , Szczecin, Poland

14. Byramjee Jeejeebhoy Government Medical College and Sassoon General Hospitals , Pune, India

15. Rheumatology Department, Kasr Al Ainy School of Medicine, Cairo University , Cairo, Egypt

16. Rheumatology Department, Fauji Foundation Hospital , Rawalpindi, Pakistan

17. Medical Faculty, Sofia University St. Kliment Ohridski , Sofia, Bulgaria

18. Department of Internal Medicine, General Hospital, National Medical Center ‘La Raza’, Instituto Mexicano del Seguro Social , Mexico City, Mexico

19. Division of Rheumatology, Department of Medicine Solna, Karolinska Institutet and Karolinska University Hospital , Stockholm, Sweden

20. Department of Rheumatology, Faculty of Medicine and Health, Örebro University , Örebro, Sweden

21. Centre for Rheumatic Diseases, King’s College London , London, UK

22. Rheumatology Department, King’s College Hospital , London, UK

23. NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals Trust , Leeds, UK

24. Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds , Leeds, UK

25. Southport and Ormskirk Hospital NHS Trust , Southport, UK

26. Department of Rheumatology, Fondazione I.R.C.C.S. Policlinico San Matteo , Pavia, Italy

27. Rheumatology Unit, Dipartimento di Medicine Interna e Terapia Medica, Università degli studi di Pavia , Pavia, Italy

28. Departamento de Reumatología Hospital de Especialidades Dr. Antonio Fraga Mouret, Centro Médico Nacional La Raza, IMSS , Mexico City, Mexico

29. Division of Rheumatology, Faculdade de Medicina FMUSP, Universidade de Sao Paulo , Sao Paulo, Brazil

30. Rheumatology Department, Saint-Joseph University , Beirut, Lebanon

31. Rheumatology Department, Hotel-Dieu de France Hospital , Beirut, Lebanon

32. Medizinische Klinik 3 – Rheumatologie und Immunologie, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg , Erlangen, Deutschland

33. Department of Rheumatology, University Hospital Zurich, University of Zurich , Zurich, Switzerland

34. Division of Musculoskeletal and Dermatological Sciences, Centre for Musculoskeletal Research, School of Biological Sciences, The University of Manchester , Manchester, UK

35. National Institute for Health Research Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, The University of Manchester , Manchester, UK

36. Department of Rheumatology, Salford Royal Hospital, Northern Care Alliance NHS Foundation Trust , Salford, UK

37. Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine , Pittsburgh, USA

38. Department of Rheumatology, Royal Wolverhampton Hospitals NHS Trust , Wolverhampton, UK

39. Department of Rheumatology, City Hospital, Sandwell and West Birmingham Hospitals NHS Trust , Birmingham, UK

Abstract

ABSTRACT Objectives We aimed to investigate the gender-based differences in idiopathic inflammatory myopathies (IIMs), with a particular focus on patient-reported outcomes, utilizing the data obtained through the international COVID-19 vaccination in autoimmune disease e-survey. Methods Patient-reported outcomes including fatigue, pain, and physical function were extracted from the COVID-19 vaccination in autoimmune disease database and compared between genders, adjusting for demographics and IIM subgroups by multivariable analysis. Inclusion body myositis (IBM) was analysed separately because of the substantial differences in outcomes. Results A total of 1197 complete responses from patients with IIMs as of 31 August 2021 were analysed. Seventy percent were women. Women were younger (58 [48–68] vs. 69 [58–75] years old, median [interquartile range], P < .001) and were more likely to suffer from autoimmune multimorbidity, defined as three or more autoimmune diseases in an individual patient (11.4% vs. 2.8%, P < .001). In non-IBM IIMs, fatigue visual analogue scale scores were higher in women (5 [3–7] vs. 4 [2–6], median [interquartile range], P = .004), whereas no significant gender-based differences were noted in IBM. Multivariable analysis in non-IBM IIMs revealed that women, residence in high-income countries, overlap myositis, and autoimmune multimorbidity were independently associated with increased fatigue. Conclusions Women with IIMs suffer from autoimmune multimorbidity and experience increased fatigue compared to men.

Publisher

Oxford University Press (OUP)

Subject

Rheumatology

Link

https://academic.oup.com/mr/advance-article-pdf/doi/10.1093/mr/road094/51920889/road094.pdf

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