Breast arterial calcification is associated with incident atrial fibrillation among older but not younger post-menopausal women

Author:

Iribarren Carlos1ORCID,Chandra Malini1,Parikh Rishi V1,Sanchez Gabriela1,Sam Danny L2,Azamian Farima Faith3,Cho Hyo-Min4,Ding Huanjun3,Molloi Sabee3,Go Alan S15

Affiliation:

1. Kaiser Permanente Division of Research , 2000 Broadway, Oakland, CA 94612 , USA

2. Kaiser Permanente Santa Clara Medical Center , 700 Lawrence Expy, Santa Clara, CA 95051 , USA

3. Department of Radiological Sciences, University of California Irvine School of Medicine , 1001 Health Sciences Rd, Irvine, CA 92617 , USA

4. Medical Measurement Team, Korea Research Institute of Standards and Science , 267 Gajeong-ro, Yuseong-gu, Daejeon 34113 , South Korea

5. Departments of Epidemiology, Biostatistics and Medicine, University of California at San Francisco , 505 Parnassus Ave, San Francisco, CA 94143 , USA

Abstract

AbstractAimsThe goal of this study was to examine the association of breast arterial calcification (BAC) presence and quantity with incident atrial fibrillation (AF) in a large cohort of post-menopausal women.Methods and resultsWe conducted a longitudinal cohort study among women free of clinically overt cardiovascular disease and AF at baseline (between October 2012 and February 2015) when they attended mammography screening. Atrial fibrillation incidence was ascertained using diagnostic codes and natural language processing. Among 4908 women, 354 incident cases of AF (7%) were ascertained after a mean (standard deviation) of 7 (2) years of follow-up. In Cox regression adjusting for a propensity score for BAC, BAC presence vs. absence was not significantly associated with AF [hazard ratio (HR) = 1.12; 95% confidence interval (CI), 0.89–1.42; P = 0.34]. However, a significant (a priori hypothesized) age by BAC interaction was found (P = 0.02) such that BAC presence was not associated with incident AF in women aged 60–69 years (HR = 0.83; 95% CI, 0.63–1.15; P = 0.26) but was significantly associated with incident AF in women aged 70–79 years (HR = 1.75; 95% CI, 1.21–2.53; P = 0.003). No evidence of dose–response relationship between BAC gradation and AF was noted in the entire cohort or in age groups separately.ConclusionOur results demonstrate, for the first time, an independent association between BAC and AF in women over age 70 years.

Funder

National Heart, Lung, and Blood Institute

Publisher

Oxford University Press (OUP)

Subject

Pharmacology

Reference31 articles.

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2. Population-based screening for atrial fibrillation;Khurshid;Circ Res,2020

3. Coronary artery calcium and risk of atrial fibrillation (from the multi-ethnic study of atherosclerosis);O'Neal;Am J Cardiol,2014

4. Coronary artery calcium progression and atrial fibrillation: the multi-ethnic study of atherosclerosis;O'Neal;Circ Cardiovasc Imaging,2015

5. Breast arterial calcification on screening mammography can predict significant coronary artery disease in women;Kelly;Clin Imaging,2018

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Women in Cardiology;European Heart Journal Open;2023-11

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