NAFLD risk alleles in PNPLA3, TM6SF2, GCKR and LYPLAL1 show divergent metabolic effects

Author:

Sliz Eeva12ORCID,Sebert Sylvain123,Würtz Peter45,Kangas Antti J5,Soininen Pasi56,Lehtimäki Terho7,Kähönen Mika8,Viikari Jorma9,Männikkö Minna10,Ala-Korpela Mika1261112,Raitakari Olli T1314,Kettunen Johannes121112

Affiliation:

1. Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland

2. Biocenter Oulu, University of Oulu, Oulu, Finland

3. Department of Genomics of Complex Diseases, School of Public Health, Imperial College London, London, UK

4. Research Programs Unit, Diabetes and Obesity, University of Helsinki, Helsinki, Finland

5. Nightingale Health Ltd., Helsinki, Finland

6. NMR Metabolomics Laboratory, School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland

7. Fimlab Laboratories, Department of Clinical Chemistry, Finnish Cardiovascular Research Center Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland

8. Department of Clinical Physiology, Tampere University Hospital and Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland

9. Division of Medicine, Department of Medicine, University of Turku, Turku University Hospital, Turku, Finland

10. Northern Finland Birth Cohorts, Faculty of Medicine, University of Oulu, Oulu, Finland

11. Computational Medicine, Faculty of Medicine, University of Oulu, Oulu, Finland

12. Population Health Science, Bristol Medical School, University of Bristol and Medical Research Council Integrative Epidemiology Unit at the University of Bristol, Bristol, UK

13. Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland

14. Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland

Funder

European Commission

Academy of Finland

Publisher

Oxford University Press (OUP)

Subject

Genetics(clinical),Genetics,Molecular Biology,General Medicine

Reference55 articles.

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3. Dyslipidemia in patients with nonalcoholic fatty liver disease;Chatrath;Semin. Liver Dis,2012

4. Metabolic profiling of fatty liver in young and middle-aged adults: cross-sectional and prospective analyses of the Young Finns Study;Kaikkonen;Hepatology,2017

5. Ketone body production is differentially altered in steatosis and non-alcoholic steatohepatitis in obese humans;Mannisto;Liver Int,2015

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