Tripolar chromosome segregation drives the association between maternal genotype at variants spanning PLK4 and aneuploidy in human preimplantation embryos

Author:

McCoy Rajiv C12ORCID,Newnham Louise J3,Ottolini Christian S4,Hoffmann Eva R35,Chatzimeletiou Katerina6,Cornejo Omar E7,Zhan Qiansheng8,Zaninovic Nikica8,Rosenwaks Zev8,Petrov Dmitri A9,Demko Zachary P10,Sigurjonsson Styrmir10,Handyside Alan H4

Affiliation:

1. Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ, USA

2. Department of Genome Sciences, University of Washington, Seattle, WA, USA

3. Genome Damage and Stability Centre, University of Sussex, Brighton, UK

4. School of Biosciences, University of Kent, Canterbury, UK

5. Department of Cellular and Molecular Medicine, DNRF Center for Chromosome Stability, University of Copenhagen, Copenhagen N, Denmark

6. Section of Reproductive Medicine, First Department of Obstetrics & Gynaecology, Aristotle University Medical School, Papageorgiou General Hospital, Thessaloniki, Greece

7. School of Biological Sciences, Washington State University, Pullman, WA, USA

8. Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine, Weill Cornell Medicine, New York, NY, USA

9. Department of Biology, Stanford University, Stanford, CA, USA

10. Natera, Inc., San Carlos, CA, USA

Funder

NIH

U.S. Patent and Trademark Office

Publisher

Oxford University Press (OUP)

Subject

Genetics(clinical),Genetics,Molecular Biology,General Medicine

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