Nonlinear network-based quantitative trait prediction from biological data

Abstract

Abstract Quantitatively predicting phenotypic variables using biomarkers is a challenging task for several reasons. First, the collected biological observations might be heterogeneous and correspond to different biological mechanisms. Second, the biomarkers used to predict the phenotype are potentially highly correlated since biological entities (genes, proteins, and metabolites) interact through unknown regulatory networks. In this paper, we present a novel approach designed to predict multivariate quantitative traits from biological data which address the 2 issues. The proposed model performs well on prediction but it is also fully parametric, with clusters of individuals and regulatory networks, which facilitates the downstream biological interpretation.