The outcomes measured and reported in observational studies of incidental and untreated intracranial meningioma: A systematic review
Author:
Millward Christopher P12ORCID, Islim Abdurrahman I12, Armstrong Terri S3ORCID, Barrington Heather4, Bell Sabrina5, Brodbelt Andrew R12, Bulbeck Helen6, Dirven Linda78ORCID, Grundy Paul L9, Javadpour Mohsen10, Keshwara Sumirat M12, Koszdin Shelli D11, Marson Anthony G112, McDermott Michael W13, Meling Torstein R14, Oliver Kathy15, Plaha Puneet16, Preusser Matthias17ORCID, Santarius Thomas18, Srikandarajah Nisaharan12, Taphoorn Martin J B78, Turner Carole18, Watts Colin19, Weller Michael20ORCID, Williamson Paula R4, Zadeh Gelareh21ORCID, Zamanipoor Najafabadi Amir H22, Jenkinson Michael D12, , Aldape Kenneth, Islim Abdurrahman I, Au Karolyn, Barnhartz-Sloan Jill, Bi Wenya Linda, Behling Felix, Brastianos Priscilla K, Brodie Chaya, Butowski Nicholas, Carlotti Carlos, Castro Ana, Cohen-Gadol Aaron, Couce Marta, Cusimano Michael D, DiMeco Francesco, Drummond Katharine, Dunn Ian F, Erker Craig, Felicella Michelle, Fountain Daniel M, Galanis Evanthia, Galldiks Norbert, Giannini Caterina, Goldbrunner Roland, Griffith Brent, Hashizume Rintaro, Oliver Hanemann C, Herold-Mende Christel, Hnenny Luke, Horbinski Craig, Huang Raymond Y, James David, Jenkinson Michael D, Jungk Christine, Jungwirth Gerhard, Kaufmann Timothy J, Krischek Boris, Kurz Sylvia, Lachance Daniel, Lafougère Christian, Lamszus Katrin, Lee Ian, Liu Jeff C, Makarenko Serge, Malta Tathiana, Mamatjan Yasin, Mansouri Alireza, Mawrin Christian, McDermott Michael, Millward Christopher P, Moliterno-Gunel Jennifer, Morokoff Andrew, Munoz David, Nassiri Farshad, Noushmehr Houtan, Ng Ho-Keung, Perry Arie, Pirouzmand Farhad, Poisson Laila M, Pollo Bianca, Ragunathan Aditya, Raleigh David, Renovanz Mirjam, Ricklefs Franz, Sahm Felix, Saladino Andrea, Santacroce Antonio, Santarius Thomas, Schittenhelm Jens, Schichor Christian, Schultz David, Schmidt Nils O, Selman Warren, Shih Helen, Sloan Andrew, Spears Julian, Snuderl Matija, Snyder James, Suppiah Suganth, Sulman Erik, Tabatabai Ghazaleh, Tatagiba Marcos, Timmer Marco, Tirapelli Daniela, Tonn Joerg C, Tsang Derek, Vogelbaum Michael A, von Deimling Andreas, Walbert Tobias, Walling Simon, Wang Justin, Wen Patrick Y, Westphal Manfred, Workewych Adriana M, Yip Stephen, Zada Gabriel, Zadeh Gelareh, Zherebitskiy Viktor
Affiliation:
1. Institute of Systems, Molecular, & Integrative Biology, University of Liverpool , Liverpool , UK 2. Department of Neurosurgery, The Walton Centre NHS Foundation Trust , Liverpool , UK 3. Neuro-Oncology Branch, Center for Cancer Research, National Cancer Institute , Bethesda, Maryland , USA 4. Institute of Population Health, University of Liverpool , Liverpool , UK 5. The Brain Tumour Charity , Hampshire , UK 6. Brainstrust – The Brain Cancer People , Isle of Wight , UK 7. Department of Neurology, Leiden University Medical Center , Leiden , The Netherlands 8. Department of Neurology, Haaglanden Medical Center , The Hague , The Netherlands 9. Department of Neurosurgery, University Hospital Southampton , Southampton , UK 10. National Centre for Neurosurgery, Beaumont Hospital , Dublin , Ireland 11. Veterans Affairs Healthcare System , Palo Alto, California , USA 12. Department of Neurology, The Walton Centre NHS Foundation Trust , Liverpool , UK 13. Division of Neuroscience, Florida International University , Miami, Florida , USA 14. Department of Neurosurgery, Copenhagen University Hospital , Copenhagen , Denmark 15. International Brain Tumour Alliance , Tadworth , UK 16. Nuffield Department of Surgical Sciences, University of Oxford , Oxford , UK 17. Division of Oncology, Department of Medicine, Medical University of Vienna , Vienna , Austria 18. Department of Neurosurgery, Addenbrooke’s Hospital & University of Cambridge , Cambridge , UK 19. Institute of Cancer and Genomic Sciences, University of Birmingham , Birmingham , UK 20. Department of Neurology, University Hospital and University of Zurich , Zurich , Switzerland 21. Department of Surgery, University of Toronto , Toronto, Ontario , Canada 22. Department of Ophthalmology, Leiden University Medical Centre, Haaglanden Medical Center, Haga Teaching Hospitals , Leiden and The Hague , The Netherlands
Abstract
Abstract
Background
The clinical management of patients with incidental intracranial meningioma varies markedly and is often based on clinician choice and observational data. Heterogeneous outcome measurement has likely hampered knowledge progress by preventing comparative analysis of similar cohorts of patients. This systematic review aimed to summarize the outcomes measured and reported in observational studies.
Methods
A systematic literature search was performed to identify published full texts describing active monitoring of adult cohorts with incidental and untreated intracranial meningioma (PubMed, EMBASE, MEDLINE, and CINAHL via EBSCO, completed January 24, 2022). Reported outcomes were extracted verbatim, along with an associated definition and method of measurement if provided. Verbatim outcomes were de-duplicated and the resulting unique outcomes were grouped under standardized outcome terms. These were classified using the taxonomy proposed by the “Core Outcome Measures in Effectiveness Trials” (COMET) initiative.
Results
Thirty-three published articles and 1 ongoing study were included describing 32 unique studies: study designs were retrospective n = 27 and prospective n = 5. In total, 268 verbatim outcomes were reported, of which 77 were defined. Following de-duplication, 178 unique verbatim outcomes remained and were grouped into 53 standardized outcome terms. These were classified using the COMET taxonomy into 9 outcome domains and 3 core areas.
Conclusions
Outcome measurement across observational studies of incidental and untreated intracranial meningioma is heterogeneous. The standardized outcome terms identified will be prioritized through an eDelphi survey and consensus meeting of key stakeholders (including patients), in order to develop a Core Outcome Set for use in future observational studies.
Funder
The Brain Tumour Charity
Publisher
Oxford University Press (OUP)
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