Clinical–epidemiological profile of confirmed cases of osteoarticular tuberculosis
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Published:2023-01-05
Issue:1
Volume:8
Page:11-17
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ISSN:2206-3552
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Container-title:Journal of Bone and Joint Infection
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language:en
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Short-container-title:J. Bone Joint Infect.
Author:
Panico Caroline Thomaz, de Oliveira Priscila Rosalba Domingos, de Carvalho Vladimir CordeiroORCID, dos Anjos Angélica Makio, de Melo Vanessa Ferreira Amorim, Lima Ana Lucia Lei Munhoz
Abstract
Abstract. Introduction: tuberculosis (TB) remains a major cause
of morbidity and mortality worldwide. The incidence of TB has increased
since the 1980s. Given the increasing prevalence of TB worldwide,
osteoarticular TB (OATB) is a significant health problem.
Methods: retrospective study of a case series of hospitalized patients with
confirmed OATB by culture or histopathological examination who were seen at
a reference orthopedic hospital in São Paulo, Brazil, from 2014 to 2019.
Results: thirty patients with confirmed bone and joint TB were seen from
2014 to 2019. The main sites of OATB were the spine (83.3 %) and the
appendicular skeleton (26.7 %). Indication of surgical treatment was
significantly related to the need for hospitalization (p=0.009) and the
increased length of hospital stay (p=0.005). Presence of sequelae at the
end of treatment was correlated with the presence of motor deficit at the
time of OATB diagnosis (p=0.035) as well as with initial presence of
functional limitation (p=0.025) and with high value of C-reactive
protein at the end of treatment (p=0.037).
Conclusions: the delay in the onset of clinical and laboratory signs of
cases of osteoarticular infections hinders the early
diagnosis and treatment of the disease, resulting in major complications
sometimes requiring surgical treatment and consequently leading to a
prolonged hospital stay, evidence of high inflammatory activities, and the
presence of neurological deficits.
Publisher
Copernicus GmbH
Subject
Infectious Diseases,Orthopedics and Sports Medicine,Surgery
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