Effect of ovariectomy on proximal tibia metaphysis and lumbar vertebral body in common marmoset monkeys-Reference-Cited by-同舟云学术

Effect of ovariectomy on proximal tibia metaphysis and lumbar vertebral body in common marmoset monkeys

Published:2019-07-12 Issue:2 Volume:6 Page:65-73
ISSN:2363-4715
Container-title:Primate Biology
language:en
Short-container-title:Primate Biol.

Author:

Schlumbohm Christina,Seidlová-Wuttke Dana,Fuchs Eberhard

Abstract

Abstract. This study aimed to investigate the effect of estrogen withdrawal on bone tissue in adult female marmoset monkeys. In a 1-year follow-up study we used quantitative computer tomography to measure total bone mineral density (BMD) of the proximal tibia and the second-last lumbar vertebral body (L5/L6) before and 1, 3, 6, and 12 months after ovariectomy. Body mass did not significantly change during the 1-year observation period. However, a significant decline of total BMD after ovariectomy was observed in the proximal tibia but not in L5/L6. In addition, regression analysis showed a significant positive relationship between BMD and body mass in both tibia and L5/L6. The results of our study support the idea that ovariectomized marmoset monkeys may serve as a model to investigate bone loss related to decline of estrogen production.

Publisher

Copernicus GmbH

Subject

Animal Science and Zoology

Link

https://pb.copernicus.org/articles/6/65/2019/pb-6-65-2019.pdf

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