Early switch to oral antibiotic therapy for the treatment of patients with bacterial native vertebral osteomyelitis: a quaternary center experience, systematic review, and meta-analysis
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Published:2022-11-23
Issue:6
Volume:7
Page:249-257
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ISSN:2206-3552
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Container-title:Journal of Bone and Joint Infection
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language:en
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Short-container-title:J. Bone Joint Infect.
Author:
Passerini Matteo, Maamari JulianORCID, Nayfeh TarekORCID, Hassett Leslie C., Tande Aaron J., Murad Mohammad H.ORCID, Temesgen Zelalem, Berbari Elie F.
Abstract
Abstract. Recent data suggest that oral therapy can be effective for bone infections.
We aim to assess the efficacy of an early switch to oral therapy (<2 weeks) compared to a non-early switch in bacterial native vertebral
osteomyelitis. We conducted a cohort study at Mayo Clinic, Rochester (MN),
between 2019–2021 combined with a systematic review, which queried multiple
databases. Data were analyzed using a random-effects model. The cohort study
included 139 patients: two received an early switch. Of 3708 citations, 13
studies were included in the final analysis. Meta-analysis demonstrated no
difference in treatment failure (odds ratio = 1.073, 95 % confidence
interval 0.370–3.116), but many studies presented high risk of bias. Current
evidence is insufficient to conclude the proportion of patients with failure
or relapse is different in the two groups. High-quality studies are
warranted before early switch can be routinely recommended.
Publisher
Copernicus GmbH
Subject
Infectious Diseases,Orthopedics and Sports Medicine,Surgery
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