Characteristics of Tibetan pig lung tissue in response to a hypoxic environment on the Qinghai–Tibet Plateau
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Published:2021-06-28
Issue:1
Volume:64
Page:283-292
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ISSN:2363-9822
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Container-title:Archives Animal Breeding
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language:en
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Short-container-title:Arch. Anim. Breed.
Author:
Yang Yanan, Gao Caixia, Yang Tianliang, Sha Yuzhu, Cai Yuan, Wang Xinrong, Yang Qiaoli, Liu Chengze, Wang Biao, Zhao ShengguoORCID
Abstract
Abstract. To adapt to the plateau environment, Tibetan pigs' lungs have developed a
unique physiological mechanism during evolution. The vascular corrosion
casting technique and scanning electron microscopy were used to understand
arterial architecture. Blood physiological index and quantitative real-time PCR (qRT-PCR) were used for
assessing whether the lung can regulate the body through anatomical, physiological
and molecular mechanisms to adapt to hypoxic environments. Our study showed
that the lungs of Tibetan pigs were heavier and wider and that the pulmonary
arteries were thicker and branched and had a denser vascular network than
those of Landrace pigs. The hemoglobin (HGB), mean corpuscular hemoglobin
concentration (MCHC) values of high-altitude pigs were significantly higher
than those of low-altitude pigs. The expression levels of HIF-1α,
EPAS1, EPO and VEGF, but not those of eNOS and EGLN1, were significantly higher in the lungs of
high-altitude pigs than in those from pigs at a lower altitude (P<0.05). These findings and a comprehensive analysis help elucidate the
pulmonary mechanism of hypoxic adaptation in pigs.
Funder
National Natural Science Foundation of China
Publisher
Copernicus GmbH
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