Determination of genetic variation within the <i>DYRK2</i> gene and its associations with milk traits in cattle
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Published:2020-09-09
Issue:2
Volume:63
Page:315-323
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ISSN:2363-9822
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Container-title:Archives Animal Breeding
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language:en
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Short-container-title:Arch. Anim. Breed.
Author:
Mao Cui,Ju Xing,Cheng Haijian,Huang Xixia,Jiang Fugui,Yao Yuni,Lan Xianyong,Song Enliang
Abstract
Abstract. To speed up the progress of marker-assisted selection (MAS) in cattle
breeding, the dual-specificity tyrosine phosphorylation-regulated kinase 2
(DYRK2), cadherin 2 (CDH2), and kinesin family member 1A (KIF1A) genes were chosen based
on our pervious genome-wide association study (GWAS) analysis results.
DYRK2 is a kinase that may participate in cell growth and/or development; it
shows phosphorylation activity toward serine, threonine, and tyrosine
fragments of proteins, and it is different from other protein kinases. The CDH2 gene
encodes a classic cadherin, which is a member of the cadherin superfamily. The
protein encoded by KIF1A is a member of the kinesin family and plays a role in
the transportation of membrane organelles along axon microtubules. We
detected insertion/deletion (InDel) variation in these three candidate genes
in 438 individual cattle (Xinjiang Brown cattle and Wagyu × Luxi
crossbreed cattle). Only DYRK2-P3-11 bp was polymorphic and genotyped. The
polymorphism information content of DYRK2-P3-11 bp was 0.336. Correlation analyses
showed that InDel polymorphism was significantly associated with six
different milk traits. These findings may aid future analyses of InDel
genotypes in cattle breeds, and speed up the progress of MAS in cattle
breeding.
Publisher
Copernicus GmbH
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