Experimental autoimmune encephalomyelitis in the common marmoset: a translationally relevant model for the cause and course of multiple sclerosis
-
Published:2019-05-10
Issue:1
Volume:6
Page:17-58
-
ISSN:2363-4715
-
Container-title:Primate Biology
-
language:en
-
Short-container-title:Primate Biol.
Author:
't Hart Bert A.
Abstract
Abstract. Aging Western societies are facing an increasing prevalence of chronic autoimmune-mediated inflammatory disorders (AIMIDs) for which treatments that are safe and effective are scarce. One of the main reasons for this situation is the lack of animal models, which accurately replicate clinical and pathological aspects of the human diseases. One important AIMID is the neuroinflammatory disease multiple sclerosis (MS), for which the mouse experimental autoimmune encephalomyelitis (EAE) model has been frequently used in preclinical research. Despite some successes, there is a long list of experimental treatments that have failed to reproduce promising effects observed in murine EAE models when they were tested in the clinic. This frustrating situation indicates a wide validity gap between mouse EAE and MS. This monography describes the development of an EAE model in nonhuman primates, which may help to bridge the gap.
Publisher
Copernicus GmbH
Subject
Animal Science and Zoology
Reference233 articles.
1. Absinta, M., Sati, P., and Reich, D. S.: Advanced MRI and staging of multiple sclerosis lesions, Nat. Rev. Neurol., 12, 358–368, https://doi.org/10.1038/nrneurol.2016.59, 2016. 2. Absinta, M., Ha, S. K., Nair, G., Sati, P., Luciano, N. J., Palisoc, M., Louveau, A., Zaghloul, K. A., Pittaluga, S., Kipnis, J., and Reich, D. S.: Human and nonhuman primate meninges harbor lymphatic vessels that can be visualized noninvasively by MRI, Elife, 6, e29738, https://doi.org/10.7554/eLife.29738, 2017. 3. Antunes, S. G., de Groot, N. G., Brok, H., Doxiadis, G., Menezes, A. A., Otting, N., and Bontrop, R. E.: The common marmoset: a new world primate species with limited Mhc class II variability, P. Natl. Acad. Sci. USA, 95, 11745–11750, 1998. 4. Araman, C., van Gent, M., Meeuwenoord, N., Heijmans, N., Marqvorsen, H. S., Faber, B. W., 't Hart, B. A., and van Kasteren, S. I.: Amyloid-like behavior of site-specific citrullinated myelin oligodendrocyte protein (MOG) peptide fragments inside EBV infected B-cells influences their cytotoxicity and autoimmunogenicty, Biochemistry, 58, 763–775, https://doi.org/10.1021/acs.biochem.8b00852, 2019. 5. Ascherio, A. and Munger, K. L.: Environmental risk factors for multiple sclerosis. Part II: Noninfectious factors, Ann. Neurol., 61, 504–513, 2007.
Cited by
10 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
|
|